Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HCD2_HUMAN
Description:hydroxysteroid (17-beta) dehydrogenase 10 [Source:HGNC Symbol;Acc:4800]
Location:chrX p11.22
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S45LDLPNsGGEAQadh_shortPhosphoSitePlus
T179GIVGMtLPIARadh_shortPhosphoSitePlus
T153GVIINtASVAAHPRD

Dephosphorylation site
HCD2_HUMAN do not have dephosphorylation site.

Mutation site
HCD2_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000168216Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.4218646787
ENSP00000168216Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.4518646787
ENSP00000168216hepatitis B virusNormal vs. CancertissueDown0.3514726492
ENSP00000168216Gastric CancerMetastasiscell lineUp2.517022644
ENSP00000168216Breast CancerTreatment (Antiestrogen-sensitive vs. Antiestrogen-resistant)cell lineUp5.114557597
ENSP00000168216hepatitis B virusNormal vs. CancertissueUp3.520525558
ENSP00000168216Non-small cell lung carcinomaMetastasiscell lineUp7.617418446
ENSP00000168216Lung CancerTreatment(none vs betulin-treatment)cell lineDown0.119085751
ENSP00000168216Gastric CancerTreatment (none vs. Vincristine-resistant)cell lineUp16525997
ENSP00000168216Gastric CancerMetastasiscell lineUp2.517022644
ENSP00000168216Gastric CancerNormal vs. CancertissueUp3.319330469
ENSP00000168216LeukemiaCancer vs. Cancer (chronic vs. acute leukemia)cell lineUp17449014
ENSP00000168216Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.115169874
ENSP00000168216Renal CancerNormal vs. CancertissueDown19164279
ENSP00000168216Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.520625496

Hyperphosphorylation site
HCD2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LYN_HUMANHCD2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
HCD2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008709cholate 7-alpha-dehydrogenase activityTASmolecular_function
GO:0005743mitochondrial inner membraneIEAcellular_component
GO:00038573-hydroxyacyl-CoA dehydrogenase activityEXPmolecular_function
GO:00470153-hydroxy-2-methylbutyryl-CoA dehydrogenase activiIEAmolecular_function
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0009083branched-chain amino acid catabolic processTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0005737cytoplasmTAScellular_component
GO:0005759mitochondrial matrixTAScellular_component
GO:0008033tRNA processingIEAbiological_process
GO:0016491oxidoreductase activityIEAmolecular_function
GO:0005739mitochondrionISScellular_component
GO:0034641cellular nitrogen compound metabolic processTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0006629lipid metabolic processTASbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0005739mitochondrionIEAcellular_component


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23