Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:H4_HUMAN
Description:histone cluster 1, H4c [Source:HGNC Symbol;Acc:4787]
Location:chr6 p22.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T74DAVTYtEHAKRHistonePhosphoSitePlus
T83KRKTVtAMDVVHistonePhosphoSitePlus
T83KRKTVtAMDVVHPRD
S2____MsGRGKGPhosphoSitePlus
T81HAKRKtVTAMDHPRD
Y89AMDVVyALKRQHistonePhosphoSitePlus
Y73RDAVTyTEHAKHistonePhosphoSitePlus
Y99QGRTLyGFGG_PhosphoSitePlus
Y52ISGLIyEETRGHistonePhosphoSitePlus
T81HAKRKtVTAMDHistonePhosphoSitePlus
S48GVKRIsGLIYEHPRD; phosphoELM; SysPTM
S2RGKGphosphoELM
S48GVKRIsGLIYEHistonePhosphoSitePlus; SysPTM
Y52ISGLIyEETRGHPRD; phosphoELM
Y89AMDVVyALKRQHPRD; phosphoELM
T31NIQGItKPAIRHistonePhosphoSitePlus
T55LIYEEtRGVLKHistonePhosphoSitePlus

Dephosphorylation site
H4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358162E64QHPIBreast Cancer16959974
ENSP00000350767E64QHPIBreast Cancer16959974
ENSP00000347168R96LCOSMICOvarian Cancer21720365
ENSP00000376663E64QHPIBreast Cancer16959974
ENSP00000353624E54DCOSMICHead and Neck Cancer21798893
ENSP00000367034E64QHPIBreast Cancer16959974
ENSP00000348258K13ICOSMICHead and Neck Cancer21798893
ENSP00000350767R37CCOSMICOvarian Cancer21720365
ENSP00000350767R40QCOSMICOvarian Cancer21720365
ENSP00000343282E64QHPIBreast Cancer16959974
ENSP00000346316E64QHPIBreast Cancer16959974
ENSP00000353624R79HCOSMICOvarian Cancer21720365
ENSP00000367034A70TCOSMICSkin Cancer21984974
ENSP00000358153E64QHPIBreast Cancer16959974
ENSP00000353624E64QHPIBreast Cancer16959974
ENSP00000353624N26ICOSMICHead and Neck Cancer21798893
ENSP00000352980E64QHPIBreast Cancer16959974
ENSP00000343282K9RBIOMARTBreast Cancer21930507, 21930502
ENSP00000366956V88FCOSMICHead and Neck Cancer21798893
ENSP00000366581R40MCOSMICOvarian Cancer20826764
ENSP00000347168R96LTCGAOvarian Cancer21720365, 18772890
ENSP00000366974R4KCOSMICHead and Neck Cancer21798893
ENSP00000289352E64QHPIBreast Cancer16959974
ENSP00000350159E64QHPIBreast Cancer16959974
ENSP00000366581E64QHPIBreast Cancer16959974
ENSP00000346316R24HCOSMICPancreatic Cancer18772397
ENSP00000366956S2CCOSMICOvarian Cancer21720365
ENSP00000366956R40GCOSMICHead and Neck Cancer21798893
ENSP00000347168G10RCOSMICPancreatic Cancer
ENSP00000366956A16VCOSMICOvarian Cancer21720365
ENSP00000366974E64QHPIBreast Cancer16959974
ENSP00000366956E64QHPIBreast Cancer16959974
ENSP00000376668E64QHPIBreast Cancer16959974
ENSP00000348258D25NCOSMICOvarian Cancer21720365
ENSP00000366581R68WCOSMICHead and Neck Cancer21798893
ENSP00000376664E64QHPIBreast Cancer16959974
ENSP00000347168E64QHPIBreast Cancer16959974
ENSP00000348258E64QSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000353624K80NBIOMARTBreast Cancer21930507, 21930502
ENSP00000376669E64QHPIBreast Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000376663Hepatocellular CarcinomaNormal vs. Cancercell lineUp5.318646787
ENSP00000376663Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp2.318491314
ENSP00000376663Gastric CancerTreatment (none vs. drug-resistant)cell lineDown0.5320625496

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y73HistoneVIRDAVTyTEHAKRKcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
TMF1_HUMANH4_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
H4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006352DNA-dependent transcription, initiationIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingNASbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0045653negative regulation of megakaryocyte differentiatiIDAbiological_process
GO:0015629actin cytoskeletonIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005576extracellular regionTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0034080CENP-A containing nucleosome assembly at centromerTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0000723telomere maintenanceTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0003677DNA bindingTASmolecular_function
GO:0006325chromatin organizationNASbiological_process
GO:0000786nucleosomeTAScellular_component
GO:0006334nucleosome assemblyTASbiological_process


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