| UniProt/SwissProt ID: | H33_HUMAN |
| Description: | H3 histone, family 3A [Source:HGNC Symbol;Acc:4764] |
| Location: | chr1 q42.12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S32 | RKSAPsTGGVK | PhosphoSitePlus; phosphoELM; RegPhos | |
| T4 | __MARtKQTAR | PhosphoSitePlus | |
| S29 | KAARKsAPSTG | AurB(Aurora B | RegPhos |
| S29 | KAARKsAPSTG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S58 | RRYQKsTELLI | Histone | PhosphoSitePlus |
| T108 | GLFEDtNLCAI | Histone | PhosphoSitePlus |
| S11 | QTARKsTGGKA | PhosphoSitePlus; HPRD; RegPhos | |
| T12 | TARKStGGKAP | RegPhos | |
| T81 | AQDFKtDLRFQ | Histone | PhosphoSitePlus |
| S11 | QTARKsTGGKA | AurB(Aurora B | RegPhos |
| S29 | KAARKsAPSTG | JNK2 | RegPhos |
| S29 | KAARKsAPSTG | MAPK9 | HPRD |
| S29 | KAARKsAPSTG | Aurora B | phosphoELM |
| S11 | QTARKsTGGKA | Aurora B | phosphoELM |
| Y42 | KKPHRyRPGTV | PhosphoSitePlus | |
| T4 | MARTKqTAR | RegPhos | |
| Y55 | REIRRyQKSTE | PhosphoSitePlus | |
| S87 | DLRFQsAAIGA | HPRD | |
| T46 | RYRPGtVALRE | PhosphoSitePlus | |
| Dephosphorylation site |
| H33_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000254810 | F105L | COSMIC | Ovarian Cancer | 20826764 | ENSP00000355778 | R3C | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000254810 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | |
| Hyperphosphorylation site |
| H33_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | H33_HUMAN | kinase -> substrate | RegPhos |
| AURKB_HUMAN | H33_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK09_HUMAN | H33_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05322 | Systemic lupus erythematosus |
| hsa05034 | Alcoholism |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05034 | Alcoholism |
| hsa05322 | Systemic lupus erythematosus |
| hsa05202 | Transcriptional misregulation in cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0006334 | nucleosome assembly | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0007420 | brain development | IEA | biological_process |
| GO:0000786 | nucleosome | IEA | cellular_component |
| GO:0009725 | response to hormone stimulus | IEA | biological_process |