| UniProt/SwissProt ID: | H31_HUMAN |
| Description: | histone cluster 1, H3h [Source:HGNC Symbol;Acc:4775] |
| Location: | chr6 p22.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y42 | KKPHRyRPGTV | PhosphoSitePlus | |
| S58 | RRYQKsTELLI | Histone | PhosphoSitePlus |
| T7 | ARTKQtARKST | PhosphoSitePlus | |
| Y55 | REIRRyQKSTE | PhosphoSitePlus | |
| S11 | QTARKsTGGKA | AurA | RegPhos |
| T12 | TARKStGGKAP | PhosphoSitePlus; RegPhos | |
| S29 | KAARKsAPATG | Aurora B | phosphoELM |
| S11 | QTARKsTGGKA | PhosphoSitePlus; phosphoELM; RegPhos | |
| S11 | QTARKsTGGKA | Aurora B | phosphoELM |
| S11 | QTARKsTGGKA | Aurora A | phosphoELM |
| S88 | LRFQSsAVMAL | Histone | PhosphoSitePlus |
| S87 | DLRFQsSAVMA | Histone | PhosphoSitePlus |
| T4 | MARTKqTAR | RegPhos | |
| T4 | __MARtKQTAR | PhosphoSitePlus | |
| T12 | TARKStGGKAP | DAPK3 | phosphoELM; RegPhos |
| T46 | RYRPGtVALRE | PhosphoSitePlus | |
| T119 | HAKRVtIMPKD | Histone | PhosphoSitePlus |
| S11 | QTARKsTGGKA | VRK1 | phosphoELM |
| S11 | QTARKsTGGKA | AurB(Aurora B | RegPhos |
| S29 | KAARKsAPATG | AurB(Aurora B | RegPhos |
| Y100 | EACEAyLVGLF | Histone | PhosphoSitePlus |
| S29 | KAARKsAPATG | PhosphoSitePlus; HPRD; RegPhos | |
| T4 | QTAR | VRK1 | phosphoELM |
| T81 | AQDFKtDLRFQ | Histone | PhosphoSitePlus |
| S29 | KAARKsAPATG | MAPK_group | phosphoELM; RegPhos |
| Dephosphorylation site |
| H31_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000350275 | Q20H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000244661 | R117Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000367062 | E98* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000244661 | A92T | COSMIC | Skin Cancer | 21984974 | ENSP00000244661 | E74K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000358160 | R27Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000329554 | T33S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000358160 | R9G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000350275 | Y42C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000329554 | Y100H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000244661 | E51Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000358160 | K37M | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000350275 | T119A | COSMIC | Pancreatic Cancer | ENSP00000350275 | Q20H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000367062 | E60* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000366999 | E98* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000358160 | R9G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000366999 | E60* | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000353581 | Breast Cancer | Treatment (none vs. 17b-Estradiol treatment) | cell line | Up | 2.7 | 18491314 |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| S11 | TKQTARKsTGGKAPR | breast adenocarcinoma | 16461563 | PhosphoSitePlus | T12 | KQTARKStGGKAPRK | prostate cancer | 18066052 | PhosphoSitePlus | S29 | ATKAARKsAPATGGV | breast cancer | 19956839 | PhosphoSitePlus | S11 | TKQTARKsTGGKAPR | breast cancer | 19956839 | PhosphoSitePlus |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AURKB_HUMAN | H31_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DAPK3_HUMAN | H31_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | H31_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05034 | Alcoholism |
| hsa05034 | Alcoholism |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05034 | Alcoholism |
| hsa05034 | Alcoholism |
| hsa05034 | Alcoholism |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05322 | Systemic lupus erythematosus |
| hsa05322 | Systemic lupus erythematosus |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05322 | Systemic lupus erythematosus |
| hsa05322 | Systemic lupus erythematosus |
| hsa05034 | Alcoholism |
| hsa05034 | Alcoholism |
| hsa05322 | Systemic lupus erythematosus |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05034 | Alcoholism |
| hsa05034 | Alcoholism |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05034 | Alcoholism |
| hsa05322 | Systemic lupus erythematosus |
| hsa05322 | Systemic lupus erythematosus |
| hsa05322 | Systemic lupus erythematosus |
| hsa05322 | Systemic lupus erythematosus |
| hsa05322 | Systemic lupus erythematosus |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0000786 | nucleosome | IEA | cellular_component |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0060968 | regulation of gene silencing | IDA | biological_process |
| GO:0006334 | nucleosome assembly | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051320 | S phase | NAS | biological_process |