Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:H31_HUMAN
Description:histone cluster 1, H3h [Source:HGNC Symbol;Acc:4775]
Location:chr6 p22.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y42KKPHRyRPGTVPhosphoSitePlus
S58RRYQKsTELLIHistonePhosphoSitePlus
T7ARTKQtARKSTPhosphoSitePlus
Y55REIRRyQKSTEPhosphoSitePlus
S11QTARKsTGGKAAurARegPhos
T12TARKStGGKAPPhosphoSitePlus; RegPhos
S29KAARKsAPATGAurora BphosphoELM
S11QTARKsTGGKAPhosphoSitePlus; phosphoELM; RegPhos
S11QTARKsTGGKAAurora BphosphoELM
S11QTARKsTGGKAAurora AphosphoELM
S88LRFQSsAVMALHistonePhosphoSitePlus
S87DLRFQsSAVMAHistonePhosphoSitePlus
T4MARTKqTARRegPhos
T4__MARtKQTARPhosphoSitePlus
T12TARKStGGKAPDAPK3phosphoELM; RegPhos
T46RYRPGtVALREPhosphoSitePlus
T119HAKRVtIMPKDHistonePhosphoSitePlus
S11QTARKsTGGKAVRK1phosphoELM
S11QTARKsTGGKAAurB(Aurora BRegPhos
S29KAARKsAPATGAurB(Aurora BRegPhos
Y100EACEAyLVGLFHistonePhosphoSitePlus
S29KAARKsAPATGPhosphoSitePlus; HPRD; RegPhos
T4QTARVRK1phosphoELM
T81AQDFKtDLRFQHistonePhosphoSitePlus
S29KAARKsAPATGMAPK_groupphosphoELM; RegPhos

Dephosphorylation site
H31_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000350275Q20HTCGAOvarian Cancer21720365, 18772890
ENSP00000244661R117QCOSMICOvarian Cancer21720365
ENSP00000367062E98*BIOMARTBreast Cancer21930507, 21930502
ENSP00000244661A92TCOSMICSkin Cancer21984974
ENSP00000244661E74KBIOMARTBreast Cancer21930507, 21930502
ENSP00000358160R27QCOSMICHead and Neck Cancer21798893
ENSP00000329554T33SCOSMICHead and Neck Cancer21798893
ENSP00000358160R9GCOSMICOvarian Cancer21720365
ENSP00000350275Y42CCOSMICHead and Neck Cancer21798893
ENSP00000329554Y100HCOSMICOvarian Cancer21720365
ENSP00000244661E51QCOSMICOvarian Cancer21720365
ENSP00000358160K37MCOSMICHead and Neck Cancer21798893
ENSP00000350275T119ACOSMICPancreatic Cancer
ENSP00000350275Q20HCOSMICOvarian Cancer21720365
ENSP00000367062E60*BIOMARTBreast Cancer21930507, 21930502
ENSP00000366999E98*BIOMARTBreast Cancer21930507, 21930502
ENSP00000358160R9GTCGAOvarian Cancer21720365, 18772890
ENSP00000366999E60*BIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000353581Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp2.718491314

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S11TKQTARKsTGGKAPRbreast adenocarcinoma16461563PhosphoSitePlus
T12KQTARKStGGKAPRKprostate cancer18066052PhosphoSitePlus
S29ATKAARKsAPATGGVbreast cancer19956839PhosphoSitePlus
S11TKQTARKsTGGKAPRbreast cancer19956839PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
AURKB_HUMANH31_HUMANkinase -> substrateRobert H Newman (2013)
DAPK3_HUMANH31_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANH31_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer
hsa05034Alcoholism
hsa05034Alcoholism
hsa05202Transcriptional misregulation in cancer
hsa05202Transcriptional misregulation in cancer
hsa05202Transcriptional misregulation in cancer
hsa05034Alcoholism
hsa05034Alcoholism
hsa05034Alcoholism
hsa05202Transcriptional misregulation in cancer
hsa05202Transcriptional misregulation in cancer
hsa05322Systemic lupus erythematosus
hsa05322Systemic lupus erythematosus
hsa05202Transcriptional misregulation in cancer
hsa05202Transcriptional misregulation in cancer
hsa05322Systemic lupus erythematosus
hsa05322Systemic lupus erythematosus
hsa05034Alcoholism
hsa05034Alcoholism
hsa05322Systemic lupus erythematosus
hsa05202Transcriptional misregulation in cancer
hsa05034Alcoholism
hsa05034Alcoholism
hsa05202Transcriptional misregulation in cancer
hsa05034Alcoholism
hsa05322Systemic lupus erythematosus
hsa05322Systemic lupus erythematosus
hsa05322Systemic lupus erythematosus
hsa05322Systemic lupus erythematosus
hsa05322Systemic lupus erythematosus

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007596blood coagulationTASbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0000786nucleosomeIEAcellular_component
GO:0005576extracellular regionTAScellular_component
GO:0060968regulation of gene silencingIDAbiological_process
GO:0006334nucleosome assemblyIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051320S phaseNASbiological_process


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