Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:H2B1D_HUMAN
Description:histone cluster 1, H2bd [Source:HGNC Symbol;Acc:4747]
Location:chr6 p22.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S57DTGISsKAMGIHistonePhosphoSitePlus
S37RSRKEsYSVYVHistonePhosphoSitePlus
S65MGIMNsFVNDIHistonePhosphoSitePlus
S15APKKGsKKAVTMST1(STK4RegPhos
Y122KAVTKyTSSK_PhosphoSitePlus
T116AVSEGtKAVTKPhosphoSitePlus
S88HYNKRsTITSRHistonePhosphoSitePlus
T89YNKRStITSREHistonePhosphoSitePlus
S113AKHAVsEGTKAPhosphoSitePlus
S56PDTGIsSKAMGHistonePhosphoSitePlus
S33KKRKRsRKESYHistonePhosphoSitePlus
Y41ESYSVyVYKVLHistonePhosphoSitePlus
S39RKESYsVYVYKHistonePhosphoSitePlus
T53QVHPDtGISSKHistonePhosphoSitePlus
Y43YSVYVyKVLKQHistonePhosphoSitePlus
T91KRSTItSREIQHistonePhosphoSitePlus
Y84SRLAHyNKRSTHistonePhosphoSitePlus
Y38SRKESySVYVYHistonePhosphoSitePlus
T120GTKAVtKYTSSPhosphoSitePlus
S124VTKYTsSK___PhosphoSitePlus

Dephosphorylation site
H2B1D_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000367008S39LCOSMICPancreatic Cancer21252315
ENSP00000289316R80CBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000289316P9LBIOMARTBreast Cancer21930507, 21930502
ENSP00000367008E77KBIOMARTBreast Cancer21930507, 21930502
ENSP00000367008A22GCOSMICOvarian Cancer21720365
ENSP00000367008P9LBIOMARTBreast Cancer21930507, 21930502
ENSP00000289316E77KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000367008Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp2.418491314
ENSP00000367008Breast CancerNormal vs. CancertissueDown0.4520739354

Hyperphosphorylation site
H2B1D_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK4_HUMANH2B1D_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05322Systemic lupus erythematosus
hsa05034Alcoholism
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000786nucleosomeIEAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0006334nucleosome assemblyIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005634nucleusIEAcellular_component


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