| UniProt/SwissProt ID: | H2A1_HUMAN |
| Description: | histone cluster 1, H2ak [Source:HGNC Symbol;Acc:4726] |
| Location: | chr6 p22.1 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S2 | MSGRGkQ | MSK1(RSK5 | RegPhos |
| T121 | LLPKKtESHHK | PhosphoSitePlus; RegPhos | |
| T102 | LLGKVtIAQGG | PhosphoSitePlus | |
| S2 | MSGRGkQ | RegPhos | |
| S2 | RGKQ | RSK-5 | phosphoELM |
| S123 | PKKTEsHHKAK | PhosphoSitePlus | |
| S2 | ____MsGRGKQ | PhosphoSitePlus | |
| Dephosphorylation site |
| H2A1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000352119 | G3V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000352119 | G3V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000352627 | M1V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000352627 | Q7H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000330307 | N69D | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000330307 | E122D | COSMIC | Head and Neck Cancer | 21798897 |
| Differential expressed protein |
| H2A1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| H2A1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KS6A5_HUMAN | H2A1_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | H2A1_HUMAN | kinase -> substrate | RegPhos |
| E2F1_HUMAN | H2A1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05034 | Alcoholism |
| hsa05322 | Systemic lupus erythematosus |
| hsa05322 | Systemic lupus erythematosus |
| hsa05322 | Systemic lupus erythematosus |
| hsa05034 | Alcoholism |
| hsa05034 | Alcoholism |
| hsa05322 | Systemic lupus erythematosus |
| hsa05322 | Systemic lupus erythematosus |
| hsa05034 | Alcoholism |
| hsa05034 | Alcoholism |
| hsa05322 | Systemic lupus erythematosus |
| hsa05034 | Alcoholism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0006334 | nucleosome assembly | IEA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0000786 | nucleosome | IEA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |