Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GUC2C_HUMAN
Description:guanylate cyclase 2C (heat stable enterotoxin receptor) [Source:HGNC Symbol;Acc:4688]
Location:chr12 p12.3
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T414MSPTFtWKNSKPhosphoSitePlus
T189TYSWStSYVYKANF_receptorPhosphoSitePlus
T404THVNKtYPVDMPhosphoSitePlus
S965LRIHVsGSTIAHPRD
Y193STSYVyKNGTEANF_receptorPhosphoSitePlus
Y940IKMPRyCLFGDGuanylate_cycPhosphoSitePlus
T399LLTYDtHVNKTPhosphoSitePlus
Y681RKETFyTLSCRPkinase_TyrPhosphoSitePlus
Y771RRLQLySRNLEPhosphoSitePlus
Y397KVLLTyDTHVNPhosphoSitePlus
T396YKVLLtYDTHVPhosphoSitePlus
T1001TTYWLtGMKDQGuanylate_cycPhosphoSitePlus
Y256GPEFLyKLKGDANF_receptorPhosphoSitePlus

Dephosphorylation site
GUC2C_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261170Y603NBIOMARTBreast Cancer21930507, 21930502
ENSP00000261170G61RGreenman2007Skin Cancer17344846, 18428421

Differential expressed protein
GUC2C_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GUC2C_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GUC2A_HUMANGUC2C_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00230Purine metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009636response to toxinIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0006182cGMP biosynthetic processIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005525GTP bindingIEAmolecular_function
GO:0009190cyclic nucleotide biosynthetic processIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0007168receptor guanylyl cyclase signaling pathwayTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0015643toxin bindingIEAmolecular_function
GO:0004383guanylate cyclase activityIEAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016849phosphorus-oxygen lyase activityIEAmolecular_function


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