| UniProt/SwissProt ID: | GTR2_HUMAN |
| Description: | solute carrier family 2 (facilitated glucose transporter), member 2 [Source:HGNC Symbol;Acc:11006] |
| Location: | chr3 q26.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S503 | EFQKKsGSAHR | PRKACA | HPRD |
| S491 | ETKGKsFEEIA | PKACa | RegPhos |
| S505 | QKKSGsAHRPK | PKACa | RegPhos |
| S505 | QKKSGsAHRPK | PRKACA | HPRD |
| S491 | ETKGKsFEEIA | PKA_group | phosphoELM; RegPhos |
| S503 | EFQKKsGSAHR | PKACa | RegPhos |
| S491 | ETKGKsFEEIA | PRKACA | HPRD |
| S505 | QKKSGsAHRPK | PKA_group | phosphoELM; RegPhos |
| S503 | EFQKKsGSAHR | PKA_group | phosphoELM; RegPhos |
| Dephosphorylation site |
| GTR2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000323568 | P419S | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000323568 | V197I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000323568 | A313T | COSMIC | Central Nervous System Neoplasms | 18772890 |
| Differential expressed protein |
| GTR2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GTR2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | GTR2_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04950 | Maturity onset diabetes of the young |
| hsa04973 | Carbohydrate digestion and absorption |
| hsa04930 | Type II diabetes mellitus |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0070837 | dehydroascorbic acid transport | IEA | biological_process |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0015149 | hexose transmembrane transporter activity | TAS | molecular_function |
| GO:0005903 | brush border | IEA | cellular_component |
| GO:0022891 | substrate-specific transmembrane transporter activ | IEA | molecular_function |
| GO:0050796 | regulation of insulin secretion | TAS | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
| GO:0055085 | transmembrane transport | TAS | biological_process |
| GO:0008645 | hexose transport | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0035428 | hexose transmembrane transport | TAS | biological_process |
| GO:0015758 | glucose transport | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005355 | glucose transmembrane transporter activity | EXP | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006112 | energy reserve metabolic process | TAS | biological_process |
| GO:0031018 | endocrine pancreas development | TAS | biological_process |
| GO:0015758 | glucose transport | TAS | biological_process |
| GO:0033300 | dehydroascorbic acid transporter activity | IEA | molecular_function |
| GO:0022857 | transmembrane transporter activity | IEA | molecular_function |
| GO:0055056 | D-glucose transmembrane transporter activity | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |