Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GSTP1_HUMAN
Description:glutathione S-transferase pi 1 [Source:HGNC Symbol;Acc:4638]
Location:chr11 q13.2
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y112LIYTNyEAGKDGST_CPhosphoSitePlus
S43TWQEGsLKASCGST_NPhosphoSitePlus
Y199LASPEyVNLPIPhosphoSitePlus
S43TWQEGsLKASCHPRD
T62QDGDLtLYQSNGST_NPhosphoSitePlus
Y50KASCLyGQLPKGST_NPhosphoSitePlus
S185YVGRLsARPKLGST_CPhosphoSitePlus
Y8PYTVVyFPVRGGST_NPhosphoSitePlus
Y109YISLIyTNYEAGST_CPhosphoSitePlus
S135FETLLsQNQGGGST_CPhosphoSitePlus
T110ISLIYtNYEAGGST_CPhosphoSitePlus
Y4__MPPyTVVYFGST_NPhosphoSitePlus
Y64GDLTLyQSNTIGST_NPhosphoSitePlus
Y80RTLGLyGKDQQPhosphoSitePlus

Dephosphorylation site
GSTP1_HUMAN do not have dephosphorylation site.

Mutation site
GSTP1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000381607Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineUp3.216319398
ENSP00000381607LeukemiaNormal vs. Cancercell lineDown0.2817022645
ENSP00000381607LeukemiaNormal vs. Cancercell lineUp2417022645
ENSP00000381607Thyroid CarcinomaNormal vs. CancertissueUp5.217194741
ENSP00000381607Prostate CancerMetastasistissueDown0.2918553995
ENSP00000381607Breast CancerMetastasistissueUp2.119053527
ENSP00000381607Oral CancerNormal vs. CancertissueUp2.516889763
ENSP00000381607MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed)cell lineDown0.4817854218
ENSP00000381607Hepatocellular CarcinomaTreatment (none vs. Suberonylanilide hydroxamic acid (SAHA) treatment)tissueDown17593366
ENSP00000381607hepatitis B virusNormal vs. CancertissueUp3.217671684
ENSP00000381607Neoplasms by Histologic TypeNormal vs. CancertissueUp312874873
ENSP00000381607Non-small cell lung carcinomaMetastasiscell lineDown17418446
ENSP00000381607Lung CancerTreatment (none vs. Mitoxantrone resistance)cell lineUp1.817593620
ENSP00000381607Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.120804217
ENSP00000381607Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.3220804217
ENSP00000381607Gastric CancerNormal vs. CancertissueDown14711373
ENSP00000381607Gastric CancerTreatment (none vs. drug-resistant)cell lineDown18309519
ENSP00000381607Breast CancerMetastasiscell lineUp4.718582095
ENSP00000381607Breast CancerMetastasiscell lineDown0.4918582095
ENSP00000381607Breast CancerTreatment (TNF-a-sensitive vs. TNF-a-resistant )cell lineUp5.419087274
ENSP00000381607Breast CancerNormal vs. CancertissueUp2.420005186
ENSP00000381607Breast CancerNormal vs. Cancercell lineDown0.07620052998
ENSP00000381607Breast CancerNormal vs. Cancercell lineDown0.1820052998
ENSP00000381607Breast CancerNormal vs. Cancercell lineDown0.07520052998
ENSP00000381607Breast CancerNormal vs. Cancercell lineDown0.2220052998
ENSP00000381607Breast CancerMetastasiscell lineUp120052998
ENSP00000381607Breast CancerMetastasiscell lineUp1.320052998
ENSP00000381607Breast CancerNormal vs. Cancercell lineDown0.03620052998
ENSP00000381607Breast CancerNormal vs. Cancercell lineDown0.05820052998
ENSP00000381607Breast CancerNormal vs. Cancercell lineDown0.08620052998
ENSP00000381607Breast CancerNormal vs. Cancercell lineDown0.1120052998
ENSP00000381607Breast CancerMetastasiscell lineUp2.120052998
ENSP00000381607Breast CancerMetastasiscell lineUp2.420052998
ENSP00000381607Breast CancerNormal vs. Cancercell lineDown0.0320198662
ENSP00000381607breast ductal carcinomaNormal vs. CancertissueDown0.01320534901
ENSP00000381607Breast CancerNormal vs. CancertissueDown20560667
ENSP00000381607Breast CancerNormal vs. CancertissueDown0.9220739354
ENSP00000381607Breast CancerNormal vs. CancertissueDown0.9220739354
ENSP00000381607Oral CancerNormal vs. CancertissueUp5.419691830
ENSP00000381607acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp6.617655343
ENSP00000381607acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp2017655343
ENSP00000381607acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp8.317655343
ENSP00000381607Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.4515169874
ENSP00000381607Uterine CancerTreatment(none vs. transfected with the pOP13 vector that containing E7)cell lineDown14997504
ENSP00000381607Gastric CancerNormal vs. CancertissueDown0.4315761955
ENSP00000381607Uterine CancerNormal vs. CancertissueUp16051329
ENSP00000381607Uterine CancerNormal vs. CancertissueUp19771267

Hyperphosphorylation site
GSTP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GSTP1_HUMANTRAF2_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa00480Glutathione metabolism
hsa00982Drug metabolism - cytochrome P450
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa05215Prostate cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006805xenobiotic metabolic processIDAbiological_process
GO:0032691negative regulation of interleukin-1 beta productiIDAbiological_process
GO:0002674negative regulation of acute inflammatory responseNASbiological_process
GO:0006469negative regulation of protein kinase activityIDAbiological_process
GO:0060547negative regulation of necrotic cell deathISSbiological_process
GO:0043409negative regulation of MAPK cascadeNASbiological_process
GO:0071638negative regulation of monocyte chemotactic proteiIDAbiological_process
GO:0006749glutathione metabolic processIDAbiological_process
GO:0097057TRAF2-GSTP1 complexIDAcellular_component
GO:0043508negative regulation of JUN kinase activityIDAbiological_process
GO:0070664negative regulation of leukocyte proliferationISSbiological_process
GO:0071222cellular response to lipopolysaccharideISSbiological_process
GO:0019207kinase regulator activityISSmolecular_function
GO:0070372regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0032873negative regulation of stress-activated MAPK cascaISSbiological_process
GO:0048147negative regulation of fibroblast proliferationISSbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0010804negative regulation of tumor necrosis factor-mediaICbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0035730S-nitrosoglutathione bindingIDAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0008432JUN kinase bindingISSmolecular_function
GO:0009890negative regulation of biosynthetic processIDAbiological_process
GO:0004364glutathione transferase activityIDAmolecular_function
GO:0032720negative regulation of tumor necrosis factor produIDAbiological_process
GO:0005622intracellularIDAcellular_component
GO:0043407negative regulation of MAP kinase activityIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0032930positive regulation of superoxide anion generationISSbiological_process
GO:0032872regulation of stress-activated MAPK cascadeISSbiological_process
GO:0035726common myeloid progenitor cell proliferationISSbiological_process
GO:0051771negative regulation of nitric-oxide synthase biosyIDAbiological_process
GO:0035732nitric oxide storageNASbiological_process
GO:0007417central nervous system developmentTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB cISSbiological_process
GO:0070373negative regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0070026nitric oxide bindingNASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0000302response to reactive oxygen speciesISSbiological_process
GO:0035731dinitrosyl-iron complex bindingIDAmolecular_function