| UniProt/SwissProt ID: | GRPR_HUMAN |
| Description: | gastrin-releasing peptide receptor [Source:HGNC Symbol;Acc:4609] |
| Location: | chrX p22.2 |
| Node attribute: | receptor |
| Phosphorylation site |
| GRPR_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| GRPR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000369643 | N243K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000369643 | N243K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000369643 | G271D | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000369643 | S326I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000369643 | Q149R | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000369643 | V246M | BIOMART | Gastric Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000369643 | Testicular Cancer | Normal vs. Cancer | cell line | Down | 18489135 | |
| Hyperphosphorylation site |
| GRPR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NMB_HUMAN | GRPR_HUMAN | ligand -> receptor | HPMR |
| LEGL_HUMAN | GRPR_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04020 | Calcium signaling pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0008528 | G-protein coupled peptide receptor activity | TAS | molecular_function |
| GO:0004946 | bombesin receptor activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0042127 | regulation of cell proliferation | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |