Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRDN_HUMAN
Description:coiled-coil domain containing 88A [Source:HGNC Symbol;Acc:25523]
Location:chr2 p16.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S595KILHEsIKETSPhosphoSitePlus
S1462GTKKSsMVALKPhosphoSitePlus
S959YKLLEsKLESTPhosphoSitePlus
S1734CGLARsVSGKTPhosphoSitePlus
T1559VNNKDtTSFEDRegPhos
S1387KFYDPsPPRRRPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T1773SNPYAtLPRASHPRD
Y876KEIGIyKESCVPhosphoSitePlus
S1844PAAADsNTTAAPhosphoSitePlus
S1837PISVDsPPAAAPhosphoSitePlus; SysPTM
S1674QIKSSsQENLLHPRD
S1736LARSVsGKTPGPhosphoSitePlus
T1673HHKIKtGSPGSPhosphoSitePlus; SysPTM
S1792TTRRTsIHDFLHPRD
S1650TGSPGsEVVTLHPRD
T1847ADSNTtAASNVPhosphoSitePlus
S1809PISVDsPPAAAHPRD
S600SIKETsSKLSKPhosphoSitePlus
Y1384DQYKFyDPSPPPhosphoSitePlus
S1702QIKSSsQENLLPhosphoSitePlus; RegPhos; SysPTM
S747ELLKAsFKKTEPhosphoSitePlus
S1498NDLVQsMVLAGPhosphoSitePlus
S1820TTRRTsIHDFLPhosphoSitePlus
S1787KLVKEsSLSRQPhosphoSitePlus
S1796RQSKDsNPYATPhosphoSitePlus
S1561NKDTTsFEDISRegPhos
S1689KSLSVsSDFLGHPRD
S1417RERQKsLTLTPAKT1HPRD
S1417RERQKsLTLTPPhosphoSitePlus
S237QSPCGsPGMKRHOOKPhosphoSitePlus
T1801SNPYAtLPRASPhosphoSitePlus; SysPTM
S1461LGTKKsSMVALPhosphoSitePlus
S1807LPRASsVISTAPhosphoSitePlus
S449EAPQKsLGHEVHOOKPhosphoSitePlus
T1761PGPRKtEDTYFPhosphoSitePlus
Y1744TPGDFyDRRTTPhosphoSitePlus
T1791GTTRRtSIHDFHPRD
S1717KSLSVsSDFLGPhosphoSitePlus
T1419RQKSLtLTPTRPhosphoSitePlus; HPRD
S913REDLVsEKLKTPhosphoSitePlus
Y1799KDSNPyATLPRPhosphoSitePlus
S1675KIKTGsPGSEVPhosphoSitePlus; RegPhos
S1647KIKTGsPGSEVHPRD
S1583SRVHAsRPASLPhosphoSitePlus
S233SSSAQsPCGSPHOOKPhosphoSitePlus
T1764RKTEDtYFISSPhosphoSitePlus
S1788LVKESsLSRQSPhosphoSitePlus
S1790KESSLsRQSKDPhosphoSitePlus
T1645HHKIKtGSPGSHPRD
Y1737KTEDTyFISSAHPRD
Y1765KTEDTyFISSAPhosphoSitePlus
S1652KRQTRsSPVLQPhosphoSitePlus
T1560NNKDTtSFEDIRegPhos
Y1381KIMDQyKFYDPPhosphoSitePlus
S1417RERQKsLTLTPAKT1(PKBRegPhos
S1278SLLNNsKLEQTHPRD
S1700K.SSSQENLLDEVMK.SSysPTM 2.0

Dephosphorylation site
GRDN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263630E1724*COSMICMelanoma21499247
ENSP00000410608P1618LBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000263630N866KCOSMICMelanoma21499247
ENSP00000338728P1617LBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000263630D1409GCOSMICOvarian Cancer21720365
ENSP00000263630L189PCOSMICOvarian Cancer21720365
ENSP00000263630P1590LBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000263630E38fs*11COSMICOvarian Cancer21720365
ENSP00000263630Q1380*COSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000410608Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp1.319714814

Hyperphosphorylation site
GRDN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANGRDN_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANGRDN_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
GRDN_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006275regulation of DNA replicationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0001932regulation of protein phosphorylationIEAbiological_process
GO:0016020membraneIDAcellular_component
GO:0043422protein kinase B bindingIEAmolecular_function
GO:0006260DNA replicationIEAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0016477cell migrationIMPbiological_process
GO:0030032lamellipodium assemblyIMPbiological_process
GO:0031929TOR signaling cascadeIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0001932regulation of protein phosphorylationISSbiological_process
GO:0003779actin bindingIDAmolecular_function
GO:0008017microtubule bindingIEAmolecular_function
GO:0005794Golgi apparatusIDAcellular_component
GO:0035091phosphatidylinositol bindingIDAmolecular_function
GO:0032956regulation of actin cytoskeleton organizationIMPbiological_process
GO:0016192vesicle-mediated transportIEAbiological_process
GO:0005829cytosolIDAcellular_component
GO:0016044cellular membrane organizationIDAbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0032148activation of protein kinase B activityIEAbiological_process
GO:0000226microtubule cytoskeleton organizationIEAbiological_process
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0031410cytoplasmic vesicleIDAcellular_component
GO:0010975regulation of neuron projection developmentIEAbiological_process
GO:0030027lamellipodiumIDAcellular_component


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