| UniProt/SwissProt ID: | GPM6A_HUMAN |
| Description: | glycoprotein M6A [Source:HGNC Symbol;Acc:4460] |
| Location: | chr4 q34.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S256 | YEDIKsKEEQE | PhosphoSitePlus; HPRD; SysPTM | |
| T10 | MEEGQtQKGCF | PKCa | RegPhos |
| T10 | MEEGQtQKGCF | PRKCA | HPRD |
| S267 | LHDIHsTRSKE | PhosphoSitePlus; RegPhos | |
| T10 | MEEGQtQKGCF | PKC_alpha | phosphoELM |
| T10 | MEEGQtQKGCF | PKCa(PKC alpha | RegPhos |
| Dephosphorylation site |
| GPM6A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377268 | R163W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000280187 | S52F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000280187 | R163W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000377268 | G53E | COSMIC | Skin Cancer | 21984974 | ENSP00000377268 | S52F | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| GPM6A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GPM6A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | GPM6A_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | GPM6A_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| GPM6A_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051491 | positive regulation of filopodium assembly | IEA | biological_process |
| GO:0070588 | calcium ion transmembrane transport | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0043025 | neuronal cell body | IEA | cellular_component |
| GO:0007416 | synapse assembly | IEA | biological_process |
| GO:0044295 | axonal growth cone | IEA | cellular_component |
| GO:0048812 | neuron projection morphogenesis | IEA | biological_process |
| GO:0009986 | cell surface | IDA | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0030175 | filopodium | IEA | cellular_component |
| GO:0043005 | neuron projection | IEA | cellular_component |
| GO:0048863 | stem cell differentiation | IDA | biological_process |
| GO:0003407 | neural retina development | IEA | biological_process |
| GO:0043197 | dendritic spine | IEA | cellular_component |
| GO:0005262 | calcium channel activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0043005 | neuron projection | ISS | cellular_component |
| GO:0001764 | neuron migration | IDA | biological_process |