| UniProt/SwissProt ID: | GNMT_HUMAN |
| Description: | glycine N-methyltransferase [Source:HGNC Symbol;Acc:4415] |
| Location: | chr6 p21.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T220 | KAHMVtLDYTV | PhosphoSitePlus | |
| S252 | PHCLAsFTELL | PhosphoSitePlus | |
| T224 | VTLDYtVQVPG | PhosphoSitePlus | |
| S10 | VYRTRsLGVAA | PRKACA | HPRD |
| Y196 | PGKNIyYKSDL | PhosphoSitePlus | |
| Y22 | GLPDQyADGEA | PhosphoSitePlus | |
| Y34 | RVWQLyIGDTR | PhosphoSitePlus | |
| S199 | NIYYKsDLTKD | PhosphoSitePlus | |
| Y197 | GKNIYyKSDLT | PhosphoSitePlus | |
| Dephosphorylation site |
| GNMT_HUMAN do not have dephosphorylation site. |
| Mutation site |
| GNMT_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000361894 | hepatitis C virus | Normal vs. Cancer | tissue | Down | 0.2 | 18715028 | ENSP00000361894 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 0.48 | 17627933 | ENSP00000361894 | hepatitis B virus | Normal vs. Cancer | tissue | Down | 0.22 | 15852300 | ENSP00000361894 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 18571811 | ENSP00000361894 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 18937283 |
| Hyperphosphorylation site |
| GNMT_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | GNMT_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00260 | Glycine, serine and threonine metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006111 | regulation of gluconeogenesis | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0046500 | S-adenosylmethionine metabolic process | IEA | biological_process |
| GO:0006555 | methionine metabolic process | IEA | biological_process |
| GO:0051289 | protein homotetramerization | IEA | biological_process |
| GO:0017174 | glycine N-methyltransferase activity | IEA | molecular_function |
| GO:0046500 | S-adenosylmethionine metabolic process | IDA | biological_process |
| GO:0017174 | glycine N-methyltransferase activity | IDA | molecular_function |
| GO:0006730 | one-carbon metabolic process | IEA | biological_process |
| GO:0051289 | protein homotetramerization | IPI | biological_process |
| GO:0008168 | methyltransferase activity | IEA | molecular_function |
| GO:0008152 | metabolic process | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016594 | glycine binding | IDA | molecular_function |
| GO:0006464 | cellular protein modification process | NAS | biological_process |
| GO:0005977 | glycogen metabolic process | IEA | biological_process |
| GO:0016594 | glycine binding | IEA | molecular_function |
| GO:0005542 | folic acid binding | IEA | molecular_function |