Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GLI2_HUMAN
Description:GLI family zinc finger 2 [Source:HGNC Symbol;Acc:4318]
Location:chr2 q14.2
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S236RALSIsPLSDAPhosphoSitePlus; HPRD
S859SYDPIsTDASRPhosphoSitePlus
S132EHYLRsVHSSPPhosphoSitePlus
T818VSSAYtVSRRSPhosphoSitePlus
S820SAYTVsRRSSGPhosphoSitePlus
T224SSPRVtPRLSRPhosphoSitePlus
S388GLRPAsPLALTPhosphoSitePlus
S808QERRDsSTSTVPhosphoSitePlus
S242PLSDAsLDLQRPhosphoSitePlus; HPRD
S143TLSMIsAARGLPhosphoSitePlus
S989VQRFHsTHNVNPhosphoSitePlus
S870RSSEAsQCSGGPhosphoSitePlus
S1194QGLQAsPGGLDHPRD
T8TSASAtASEKQPhosphoSitePlus
T860YDPIStDASRRPhosphoSitePlus
S10ASATAsEKQEAPhosphoSitePlus
S149AARGLsPADVAPhosphoSitePlus; HPRD
S234RKRALsISPLSPhosphoSitePlus; HPRD
S1187QYPGYsPQGLQHPRD
S941GPRRGsDGPTYPhosphoSitePlus
S824VSRRSsGISPYPhosphoSitePlus
S239SISPLsDASLDHPRD

Dephosphorylation site
GLI2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354586S1482ICOSMICOvarian Cancer21720365
ENSP00000354586V643ITCGAOvarian Cancer21720365, 18772890
ENSP00000354586S1482ITCGAOvarian Cancer21720365, 18772890
ENSP00000390436E469QTCGAOvarian Cancer21720365, 18772890
ENSP00000354586P1429SCOSMICSkin Cancer21984974
ENSP00000354586S92NCOSMICOvarian Cancer21720365
ENSP00000354586P63LCOSMICOvarian Cancer21720365
ENSP00000354586G1519DTCGAOvarian Cancer21720365, 18772890
ENSP00000354586R479QBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000354586M1359ICOSMICHead and Neck Cancer21798893
ENSP00000354586T437PTCGAOvarian Cancer21720365, 18772890
ENSP00000390436V643ITCGAOvarian Cancer21720365, 18772890
ENSP00000354586P63LTCGAOvarian Cancer21720365, 18772890
ENSP00000390436G1519DTCGAOvarian Cancer21720365, 18772890
ENSP00000354586Q1472*BIOMARTBrain Cancer21930507, 21930502
ENSP00000390436S92NTCGAOvarian Cancer21720365, 18772890
ENSP00000354586E469QCOSMICOvarian Cancer21720365
ENSP00000354586R606LCOSMICBreast Cancer20668451
ENSP00000354586A325SCOSMICOvarian Cancer21720365
ENSP00000354586S92NTCGAOvarian Cancer21720365, 18772890
ENSP00000390436P63LTCGAOvarian Cancer21720365, 18772890
ENSP00000354586A325STCGAOvarian Cancer21720365, 18772890
ENSP00000354586E469QTCGAOvarian Cancer21720365, 18772890
ENSP00000390436A325STCGAOvarian Cancer21720365, 18772890
ENSP00000354586V643ICOSMICOvarian Cancer21720365
ENSP00000390436S1482ITCGAOvarian Cancer21720365, 18772890
ENSP00000390436T437PTCGAOvarian Cancer21720365, 18772890
ENSP00000354586G1519DCOSMICOvarian Cancer21720365
ENSP00000354586R264*COSMICOvarian Cancer20668451

Differential expressed protein
GLI2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GLI2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GLI2_HUMANBCL2_HUMANTF -> target geneTRANSFAC
GLI2_HUMANGLI1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
GLI2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007418ventral midline developmentISSbiological_process
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0007224smoothened signaling pathwayIDAbiological_process
GO:0060603mammary gland duct morphogenesisIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0060322head developmentIEAbiological_process
GO:0021983pituitary gland developmentISSbiological_process
GO:0030879mammary gland developmentISSbiological_process
GO:0009954proximal/distal pattern formationIEAbiological_process
GO:0042475odontogenesis of dentin-containing toothISSbiological_process
GO:0048856anatomical structure developmentIEAbiological_process
GO:0071407cellular response to organic cyclic compoundIEAbiological_process
GO:0048566embryonic digestive tract developmentISSbiological_process
GO:0021513spinal cord dorsal/ventral patterningIEAbiological_process
GO:0007389pattern specification processISSbiological_process
GO:0032331negative regulation of chondrocyte differentiationIEAbiological_process
GO:0021696cerebellar cortex morphogenesisISSbiological_process
GO:0021776smoothened signaling pathway involved in spinal coIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0007442hindgut morphogenesisIEAbiological_process
GO:0021517ventral spinal cord developmentISSbiological_process
GO:0021513spinal cord dorsal/ventral patterningISSbiological_process
GO:0021965spinal cord ventral commissure morphogenesisISSbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0048589developmental growthIEAbiological_process
GO:0009913epidermal cell differentiationIDAbiological_process
GO:0007389pattern specification processIEAbiological_process
GO:0048646anatomical structure formation involved in morphogIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0035295tube developmentIEAbiological_process
GO:0048754branching morphogenesis of a tubeIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0008270zinc ion bindingIDAmolecular_function
GO:0009953dorsal/ventral pattern formationIEAbiological_process
GO:0007418ventral midline developmentIEAbiological_process
GO:0001501skeletal system developmentISSbiological_process
GO:0031512motile primary ciliumIEAcellular_component
GO:0001649osteoblast differentiationIDAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0048666neuron developmentIEAbiological_process
GO:0021508floor plate formationIEAbiological_process
GO:0021517ventral spinal cord developmentIEAbiological_process
GO:0030879mammary gland developmentIEAbiological_process
GO:0005929ciliumIEAcellular_component
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0060513prostatic bud formationIEAbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0021696cerebellar cortex morphogenesisIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0030902hindbrain developmentIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0021775smoothened signaling pathway involved in ventral sIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0048566embryonic digestive tract developmentIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0030902hindbrain developmentISSbiological_process
GO:0001822kidney developmentISSbiological_process
GO:0021915neural tube developmentIEAbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0008589regulation of smoothened signaling pathwayIEAbiological_process
GO:0007442hindgut morphogenesisISSbiological_process
GO:0009954proximal/distal pattern formationISSbiological_process
GO:0008283cell proliferationIDAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0048666neuron developmentISSbiological_process
GO:0045740positive regulation of DNA replicationIDAbiological_process
GO:0021775smoothened signaling pathway involved in ventral sISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0048754branching morphogenesis of a tubeISSbiological_process
GO:0007411axon guidanceISSbiological_process
GO:0021904dorsal/ventral neural tube patterningIEAbiological_process
GO:0048589developmental growthISSbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0021965spinal cord ventral commissure morphogenesisIEAbiological_process
GO:0007224smoothened signaling pathwayIEAbiological_process
GO:0001649osteoblast differentiationIEAbiological_process
GO:0090103cochlea morphogenesisIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0021983pituitary gland developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0002076osteoblast developmentISSbiological_process
GO:0021508floor plate formationISSbiological_process
GO:0005622intracellularIEAcellular_component
GO:0033089positive regulation of T cell differentiation in tISSbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0021938smoothened signaling pathway involved in regulatioIEAbiological_process
GO:0002076osteoblast developmentIEAbiological_process
GO:0035295tube developmentISSbiological_process
GO:0060831smoothened signaling pathway involved in dorsal/veIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0042733embryonic digit morphogenesisIEAbiological_process
GO:0007507heart developmentISSbiological_process
GO:0030324lung developmentISSbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0060032notochord regressionIEAbiological_process
GO:0001501skeletal system developmentIEAbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0002009morphogenesis of an epitheliumIEAbiological_process