Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GHRL_HUMAN
Description:ghrelin/obestatin prepropeptide [Source:HGNC Symbol;Acc:18129]
Location:chr3 p25.3
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S41QQRKEsKKPPAMotilin_ghrelinPhosphoSitePlus

Dephosphorylation site
GHRL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000416768*106CCOSMICOvarian Cancer21720365
ENSP00000335074G88VCOSMICOvarian Cancer21720365

Differential expressed protein
GHRL_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GHRL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GHRL_HUMANGHSR_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
GHRL_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0040013negative regulation of locomotionIEAbiological_process
GO:0009755hormone-mediated signaling pathwayTASbiological_process
GO:0043400cortisol secretionNASbiological_process
GO:0030296protein tyrosine kinase activator activityIMPmolecular_function
GO:0001664G-protein coupled receptor bindingISSmolecular_function
GO:0032100positive regulation of appetiteISSbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0001696gastric acid secretionIEAbiological_process
GO:0030141secretory granuleTAScellular_component
GO:0030424axonIDAcellular_component
GO:0046697decidualizationIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayISSbiological_process
GO:0031768ghrelin receptor bindingIEAmolecular_function
GO:0046676negative regulation of insulin secretionIEAbiological_process
GO:0005576extracellular regionIDAcellular_component
GO:0050728negative regulation of inflammatory responseIDAbiological_process
GO:0005788endoplasmic reticulum lumenTAScellular_component
GO:0016608growth hormone-releasing hormone activityISSmolecular_function
GO:0005615extracellular spaceIDAcellular_component
GO:0051216cartilage developmentNASbiological_process
GO:0008343adult feeding behaviorIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0001664G-protein coupled receptor bindingIEAmolecular_function
GO:0042127regulation of cell proliferationIDAbiological_process
GO:0031768ghrelin receptor bindingISSmolecular_function
GO:0045409negative regulation of interleukin-6 biosynthetic IDAbiological_process
GO:0061098positive regulation of protein tyrosine kinase actIMPbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0009725response to hormone stimulusIDAbiological_process
GO:0008154actin polymerization or depolymerizationIDAbiological_process
GO:0008343adult feeding behaviorISSbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationISSbiological_process
GO:0051965positive regulation of synapse assemblyIDAbiological_process
GO:0051464positive regulation of cortisol secretionIDAbiological_process
GO:0032095regulation of response to foodIEAbiological_process
GO:0032691negative regulation of interleukin-1 beta productiIDAbiological_process
GO:0060399positive regulation of growth hormone receptor sigICbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0060079regulation of excitatory postsynaptic membrane potIEAbiological_process
GO:0030252growth hormone secretionTASbiological_process
GO:0032100positive regulation of appetiteIEAbiological_process
GO:0001937negative regulation of endothelial cell proliferatIDAbiological_process
GO:0043627response to estrogen stimulusIDAbiological_process
GO:0005179hormone activityIEAmolecular_function
GO:0042322negative regulation of circadian sleep/wake cycle,IDAbiological_process
GO:0006006glucose metabolic processNASbiological_process
GO:0051461positive regulation of corticotropin secretionIDAbiological_process
GO:0040018positive regulation of multicellular organism growICbiological_process
GO:0016608growth hormone-releasing hormone activityIEAmolecular_function
GO:0032024positive regulation of insulin secretionIEAbiological_process
GO:0016358dendrite developmentIDAbiological_process
GO:0060124positive regulation of growth hormone secretionIDAbiological_process
GO:0046010positive regulation of circadian sleep/wake cycle,IDAbiological_process
GO:0032024positive regulation of insulin secretionISSbiological_process
GO:0016525negative regulation of angiogenesisNASbiological_process
GO:0042536negative regulation of tumor necrosis factor biosyIDAbiological_process
GO:0032097positive regulation of response to foodIEAbiological_process
GO:0000187activation of MAPK activityIMPbiological_process
GO:0005576extracellular regionIEAcellular_component