| UniProt/SwissProt ID: | GFPT1_HUMAN |
| Description: | glutamine--fructose-6-phosphate transaminase 1 [Source:HGNC Symbol;Acc:4241] |
| Location: | chr2 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S205 | GTRRGsPLLIG | PKC_group | RegPhos |
| S235 | RTQIGsKFTRW | PhosphoSitePlus | |
| S235 | RTQIGsKFTRW | PKA_group | phosphoELM; RegPhos |
| S235 | RTQIGsKFTRW | PKC_group | RegPhos |
| T149 | ESETDtETIAK | GATase_2 | PhosphoSitePlus |
| S557 | LYHQKsVLIMG | SIS | PhosphoSitePlus |
| T151 | ETDTEtIAKLV | HPRD | |
| S235 | KDKKGsCNLSR | PRKCA | HPRD |
| S205 | GTRRGsPLLIG | PRKCA | HPRD |
| S261 | LSRVDsTTCLF | PhosphoSitePlus; phosphoELM; RegPhos; SysPTM | |
| S205 | GTRRGsPLLIG | PKA_group | phosphoELM; RegPhos |
| S253 | KDKKGsCNLSR | PhosphoSitePlus | |
| T245 | RVDSTtCLFPV | HPRD | |
| T244 | SRVDStTCLFP | HPRD | |
| S235 | RTQIGsKFTRW | PKCa | RegPhos |
| T467 | VGITNtVGSSI | SIS | PhosphoSitePlus |
| S205 | GTRRGsPLLIG | GATase_2 | PhosphoSitePlus |
| T263 | RVDSTtCLFPV | PhosphoSitePlus | |
| S470 | TNTVGsSISRE | SIS | PhosphoSitePlus |
| T262 | SRVDStTCLFP | PhosphoSitePlus; phosphoELM; SysPTM | |
| S473 | VGSSIsRETDC | SIS | PhosphoSitePlus |
| S257 | GSCNLsRVDST | PhosphoSitePlus | |
| T376 | LIACGtSYHAG | HPRD | |
| S243 | LSRVDsTTCLF | HPRD | |
| Y553 | LATELyHQKSV | SIS | PhosphoSitePlus |
| T449 | VGITNtVGSSI | HPRD | |
| S205 | GTRRGsPLLIG | PKCa | RegPhos |
| Dephosphorylation site |
| GFPT1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000354347 | E277K | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000349860 | Breast Cancer | Treatment (tamoxifen-sensitive vs. tamoxifen-resistant) | tissue | Down | 0.42 | 19329653 | ENSP00000349860 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.78 | 20739354 | ENSP00000349860 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.78 | 20739354 | ENSP00000349860 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 |
| Hyperphosphorylation site |
| GFPT1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | GFPT1_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | GFPT1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00250 | Alanine, aspartate and glutamate metabolism |
| hsa01100 | Metabolic pathways |
| hsa00520 | Amino sugar and nucleotide sugar metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016597 | amino acid binding | IEA | molecular_function |
| GO:0032869 | cellular response to insulin stimulus | IEA | biological_process |
| GO:0045719 | negative regulation of glycogen biosynthetic proce | IEA | biological_process |
| GO:0006488 | dolichol-linked oligosaccharide biosynthetic proce | TAS | biological_process |
| GO:0004360 | glutamine-fructose-6-phosphate transaminase (isome | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0006047 | UDP-N-acetylglucosamine metabolic process | IEA | biological_process |
| GO:0030968 | endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0006987 | activation of signaling protein activity involved | TAS | biological_process |
| GO:0006002 | fructose 6-phosphate metabolic process | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0018279 | protein N-linked glycosylation via asparagine | TAS | biological_process |
| GO:0016051 | carbohydrate biosynthetic process | IEA | biological_process |
| GO:0006042 | glucosamine biosynthetic process | IEA | biological_process |
| GO:0032868 | response to insulin stimulus | IEA | biological_process |
| GO:0009744 | response to sucrose stimulus | IEA | biological_process |
| GO:0043687 | post-translational protein modification | TAS | biological_process |
| GO:0006048 | UDP-N-acetylglucosamine biosynthetic process | IEA | biological_process |
| GO:0008152 | metabolic process | IEA | biological_process |
| GO:0044267 | cellular protein metabolic process | TAS | biological_process |
| GO:0051289 | protein homotetramerization | IEA | biological_process |
| GO:0030246 | carbohydrate binding | IEA | molecular_function |
| GO:0006541 | glutamine metabolic process | IEA | biological_process |
| GO:0006112 | energy reserve metabolic process | TAS | biological_process |
| GO:0005975 | carbohydrate metabolic process | IEA | biological_process |