Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GFPT1_HUMAN
Description:glutamine--fructose-6-phosphate transaminase 1 [Source:HGNC Symbol;Acc:4241]
Location:chr2 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S205GTRRGsPLLIGPKC_groupRegPhos
S235RTQIGsKFTRWPhosphoSitePlus
S235RTQIGsKFTRWPKA_groupphosphoELM; RegPhos
S235RTQIGsKFTRWPKC_groupRegPhos
T149ESETDtETIAKGATase_2PhosphoSitePlus
S557LYHQKsVLIMGSISPhosphoSitePlus
T151ETDTEtIAKLVHPRD
S235KDKKGsCNLSRPRKCAHPRD
S205GTRRGsPLLIGPRKCAHPRD
S261LSRVDsTTCLFPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S205GTRRGsPLLIGPKA_groupphosphoELM; RegPhos
S253KDKKGsCNLSRPhosphoSitePlus
T245RVDSTtCLFPVHPRD
T244SRVDStTCLFPHPRD
S235RTQIGsKFTRWPKCaRegPhos
T467VGITNtVGSSISISPhosphoSitePlus
S205GTRRGsPLLIGGATase_2PhosphoSitePlus
T263RVDSTtCLFPVPhosphoSitePlus
S470TNTVGsSISRESISPhosphoSitePlus
T262SRVDStTCLFPPhosphoSitePlus; phosphoELM; SysPTM
S473VGSSIsRETDCSISPhosphoSitePlus
S257GSCNLsRVDSTPhosphoSitePlus
T376LIACGtSYHAGHPRD
S243LSRVDsTTCLFHPRD
Y553LATELyHQKSVSISPhosphoSitePlus
T449VGITNtVGSSIHPRD
S205GTRRGsPLLIGPKCaRegPhos

Dephosphorylation site
GFPT1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354347E277KCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000349860Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueDown0.4219329653
ENSP00000349860Breast CancerNormal vs. CancertissueUp0.7820739354
ENSP00000349860Breast CancerNormal vs. CancertissueUp0.7820739354
ENSP00000349860Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
GFPT1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANGFPT1_HUMANkinase -> substrateRegPhos
KPCA_HUMANGFPT1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00250Alanine, aspartate and glutamate metabolism
hsa01100Metabolic pathways
hsa00520Amino sugar and nucleotide sugar metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016597amino acid bindingIEAmolecular_function
GO:0032869cellular response to insulin stimulusIEAbiological_process
GO:0045719negative regulation of glycogen biosynthetic proceIEAbiological_process
GO:0006488dolichol-linked oligosaccharide biosynthetic proceTASbiological_process
GO:0004360glutamine-fructose-6-phosphate transaminase (isomeIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0006047UDP-N-acetylglucosamine metabolic processIEAbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0006002fructose 6-phosphate metabolic processIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0018279protein N-linked glycosylation via asparagineTASbiological_process
GO:0016051carbohydrate biosynthetic processIEAbiological_process
GO:0006042glucosamine biosynthetic processIEAbiological_process
GO:0032868response to insulin stimulusIEAbiological_process
GO:0009744response to sucrose stimulusIEAbiological_process
GO:0043687post-translational protein modificationTASbiological_process
GO:0006048UDP-N-acetylglucosamine biosynthetic processIEAbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0051289protein homotetramerizationIEAbiological_process
GO:0030246carbohydrate bindingIEAmolecular_function
GO:0006541glutamine metabolic processIEAbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0005975carbohydrate metabolic processIEAbiological_process


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