Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GDF2_HUMAN
Description:growth differentiation factor 2 [Source:HGNC Symbol;Acc:4217]
Location:chrHG1211_PATCH q11.
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T102TSDKStTPASNTGFb_propeptidePhosphoSitePlus
T103SDKSTtPASNITGFb_propeptidePhosphoSitePlus
T293SKDGStEAGESHPRD
S312HVAAGsTLARRHPRD
S69VDFLRsLNLSGTGFb_propeptidePhosphoSitePlus
S263SNDHSsGTKETPhosphoSitePlus
S277LREMIsHEQESPhosphoSitePlus

Dephosphorylation site
GDF2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000249598G359VCOSMICHead and Neck Cancer21798893
ENSP00000249598T330ICOSMICMelanoma21499247
ENSP00000249598A321GCOSMICOvarian Cancer21720365

Differential expressed protein
GDF2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GDF2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GDF2_HUMANACVL1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
GDF2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045766positive regulation of angiogenesisIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0030513positive regulation of BMP signaling pathwayIEAbiological_process
GO:0030308negative regulation of cell growthIDAbiological_process
GO:0010862positive regulation of pathway-restricted SMAD proIDAbiological_process
GO:0001569patterning of blood vesselsIDAbiological_process
GO:0032757positive regulation of interleukin-8 productionIDAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:2000279negative regulation of DNA biosynthetic processIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0040007growthIEAbiological_process
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0043537negative regulation of blood vessel endothelial ceTASbiological_process
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0032924activin receptor signaling pathwayIDAbiological_process
GO:0006879cellular iron ion homeostasisTASbiological_process
GO:0001937negative regulation of endothelial cell proliferatIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0001938positive regulation of endothelial cell proliferatIEAbiological_process
GO:0016525negative regulation of angiogenesisTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0001938positive regulation of endothelial cell proliferatIDAbiological_process
GO:0001503ossificationTASbiological_process
GO:0001570vasculogenesisIEAbiological_process
GO:0010596negative regulation of endothelial cell migrationIDAbiological_process
GO:0030509BMP signaling pathwayIDAbiological_process
GO:0045603positive regulation of endothelial cell differentiIEAbiological_process
GO:0008156negative regulation of DNA replicationTASbiological_process
GO:0060389pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0048514blood vessel morphogenesisIDAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051216cartilage developmentTASbiological_process
GO:0045669positive regulation of osteoblast differentiationIEAbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0005125cytokine activityIEAmolecular_function
GO:0001649osteoblast differentiationIEAbiological_process