Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GCKR_HUMAN
Description:glucokinase (hexokinase 4) regulator [Source:HGNC Symbol;Acc:4196]
Location:chr2 p23.3
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T306RAHQVtYSQSPPhosphoSitePlus
T315SPKIAtLMKSVPhosphoSitePlus
T280LAAHKtVDQGIPhosphoSitePlus
S321LMKSVsTSLEKPhosphoSitePlus

Dephosphorylation site
GCKR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264717R361HTCGA, COSMICOvarian Cancer21720365, 18772890

Differential expressed protein
GCKR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GCKR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GCKR_HUMANGSK3B_HUMANkinase -> substrateNetPath

Function Annotation
KEGG Pathway
GCKR_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004857enzyme inhibitor activityIEAmolecular_function
GO:0005975carbohydrate metabolic processIEAbiological_process
GO:0019899enzyme bindingIEAmolecular_function
GO:0055085transmembrane transportTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0070095fructose-6-phosphate bindingIDAmolecular_function
GO:0030246carbohydrate bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0000060protein import into nucleus, translocationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0008645hexose transportTASbiological_process
GO:0001678cellular glucose homeostasisIEAbiological_process
GO:0033132negative regulation of glucokinase activityIEAbiological_process
GO:0043086negative regulation of catalytic activityIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0015758glucose transportTASbiological_process
GO:0046415urate metabolic processIMPbiological_process
GO:0033133positive regulation of glucokinase activityIEAbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0009750response to fructose stimulusIEAbiological_process
GO:0070328triglyceride homeostasisIMPbiological_process
GO:0010827regulation of glucose transportTASbiological_process


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