Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GATA6_HUMAN
Description:GATA binding protein 6 [Source:HGNC Symbol;Acc:4174]
Location:chr18 q11.2
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S266ARFPYsPSPPMGATA-NPhosphoSitePlus
S377VPRGPsADLLEGATA-NPhosphoSitePlus
S268FPYSPsPPMANHPRD
S122FPYSPsPPMANphosphoELM
S437KRVPSsRRLGLPhosphoSitePlus; HPRD
Y282REPGGyAAAGSGATA-NPhosphoSitePlus
T34AREPStPPSPIPhosphoSitePlus
S523STSSNsDDCSKPhosphoSitePlus
T534NTSPTtQPTASHPRD
S436QKRVPsSRRLGPhosphoSitePlus; HPRD
Y188ASSPVyVPTTRGATA-NPhosphoSitePlus
S37PSTPPsPISSSPhosphoSitePlus
S120ARFPYsPSPPMphosphoELM
S266ARFPYsPSPPMHPRD
S268FPYSPsPPMANGATA-NPhosphoSitePlus
T530DCSKNtSPTTQHPRD

Dephosphorylation site
GATA6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000269216A549VTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000269216G158SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000269216S531YCOSMICSkin Cancer21984974
ENSP00000269216A549VCOSMICCentral Nervous System Neoplasms18772890
ENSP00000269216G158STCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
GATA6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GATA6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GATA6_HUMANTFF2_HUMANTF -> target geneTRANSFAC
GATA6_HUMANHNF4A_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
GATA6_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0055007cardiac muscle cell differentiationIEAbiological_process
GO:0060947cardiac vascular smooth muscle cell differentiatioIMPbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0071371cellular response to gonadotropin stimulusIEAbiological_process
GO:0007493endodermal cell fate determinationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0008134transcription factor bindingIPImolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010468regulation of gene expressionIEAbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0071158positive regulation of cell cycle arrestIDAbiological_process
GO:0030855epithelial cell differentiationIEAbiological_process
GO:0070848response to growth factor stimulusIDAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0008584male gonad developmentIEPbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0032912negative regulation of transforming growth factor IMPbiological_process
GO:0071456cellular response to hypoxiaIDAbiological_process
GO:0001103RNA polymerase II repressing transcription factor IEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0048645organ formationIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0045766positive regulation of angiogenesisIDAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0071773cellular response to BMP stimulusIEAbiological_process
GO:0032911negative regulation of transforming growth factor IMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0060575intestinal epithelial cell differentiationIDAbiological_process
GO:0006644phospholipid metabolic processIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0035239tube morphogenesisIEAbiological_process
GO:0060430lung saccule developmentIEAbiological_process
GO:0003310pancreatic A cell differentiationIEAbiological_process
GO:0051145smooth muscle cell differentiationIMPbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0060510Type II pneumocyte differentiationIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0031016pancreas developmentIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0003309type B pancreatic cell differentiationIEAbiological_process
GO:0042493response to drugIMPbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0003148outflow tract septum morphogenesisIMPbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0060045positive regulation of cardiac muscle cell prolifeIEAbiological_process
GO:0000981sequence-specific DNA binding RNA polymerase II trIMPmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0060486Clara cell differentiationIEAbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific IEAmolecular_function
GO:0019901protein kinase bindingIPImolecular_function
GO:0051891positive regulation of cardioblast differentiationIEAbiological_process
GO:0007492endoderm developmentIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function