| UniProt/SwissProt ID: | GASR_HUMAN |
| Description: | cholecystokinin B receptor [Source:HGNC Symbol;Acc:1571] |
| Location: | chr11 p15.4 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S434 | SIASLsRLSYT | PhosphoSitePlus | |
| T443 | YTTIStLGPG_ | PhosphoSitePlus | |
| S442 | SYTTIsTLGPG | PhosphoSitePlus | |
| T439 | SRLSYtTISTL | PhosphoSitePlus | |
| T440 | RLSYTtISTLG | PhosphoSitePlus | |
| S437 | SLSRLsYTTIS | PhosphoSitePlus | |
| Y294 | DSDGCyVQLPR | 7tm_1 | PhosphoSitePlus |
| Y438 | LSRLSyTTIST | PhosphoSitePlus | |
| Y61 | IRITLyAVIFL | TM | PhosphoSitePlus |
| Dephosphorylation site |
| GASR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000335544 | G267V | COSMIC | Lung Cancer | 20668451 | ENSP00000335544 | A327P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000335544 | R395C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000335544 | I241F | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000335544 | V69I | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000335544 | A431D | COSMIC | Lung Cancer | 20668451 | ENSP00000335544 | C405F | COSMIC | Lung Cancer | 20668451 | ENSP00000335544 | A327P | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000335544 | D256N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000335544 | V98F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000435534 | D256N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000435534 | L375M | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000335544 | R278H | COSMIC | Lung Cancer | 20668451 | ENSP00000335544 | L306M | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| GASR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GASR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CCKN_HUMAN | GASR_HUMAN | ligand -> receptor | HPMR |
| GAST_HUMAN | GASR_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04971 | Gastric acid secretion |
| hsa04020 | Calcium signaling pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity | TAS | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0004951 | cholecystokinin receptor activity | TAS | molecular_function |
| GO:0005887 | integral to plasma membrane | IC | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007200 | phospholipase C-activating G-protein coupled recep | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007204 | elevation of cytosolic calcium ion concentration | IDA | biological_process |
| GO:0031741 | type B gastrin/cholecystokinin receptor binding | IDA | molecular_function |
| GO:0007631 | feeding behavior | TAS | biological_process |
| GO:0008284 | positive regulation of cell proliferation | IDA | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | NAS | biological_process |
| GO:0015054 | gastrin receptor activity | IDA | molecular_function |
| GO:0007586 | digestion | TAS | biological_process |
| GO:0007600 | sensory perception | TAS | biological_process |
| GO:0004435 | phosphatidylinositol phospholipase C activity | TAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |