| UniProt/SwissProt ID: | GALR1_HUMAN |
| Description: | galanin receptor 1 [Source:HGNC Symbol;Acc:4132] |
| Location: | chr18 q23 |
| Node attribute: | receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y220 | LICFCyAKVLN | 7tm_1; TM | PhosphoSitePlus |
| S144 | HSRRSsSLRVS | 7tm_1 | PhosphoSitePlus |
| S143 | VHSRRsSSLRV | 7tm_1 | PhosphoSitePlus |
| Y209 | TFVFGyLLPLL | 7tm_1; TM | PhosphoSitePlus |
| Dephosphorylation site |
| GALR1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000299727 | H263Q | COSMIC | Lung Cancer | 20668451 | ENSP00000299727 | H289R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000299727 | H327Q | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000299727 | E239Q | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| GALR1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GALR1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GCSAM_HUMAN | GALR1_HUMAN | ligand -> receptor | HPMR |
| GALP_HUMAN | GALR1_HUMAN | ligand -> receptor | HPMR |
| IP3KA_HUMAN | GALR1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042923 | neuropeptide binding | IEA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0007586 | digestion | TAS | biological_process |
| GO:0007194 | negative regulation of adenylate cyclase activity | TAS | biological_process |
| GO:0007189 | adenylate cyclase-activating G-protein coupled rec | IEA | biological_process |
| GO:0004966 | galanin receptor activity | IEA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0007218 | neuropeptide signaling pathway | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |