Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FZD7_HUMAN
Description:frizzled family receptor 7 [Source:HGNC Symbol;Acc:4045]
Location:chr2 q33.1
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y35AGAQPyHGEKGPhosphoSitePlus
S11AAAPLsSLGLCPhosphoSitePlus
S27LLGALsAGAGAPhosphoSitePlus

Dephosphorylation site
FZD7_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000286201P285SCOSMICMelanoma
ENSP00000286201A390TCOSMICOvarian Cancer21720365
ENSP00000286201A313fs*55COSMICOvarian Cancer21720365
ENSP00000286201P218SCOSMICMelanoma
ENSP00000286201R325HCOSMICHead and Neck Cancer21798893
ENSP00000286201A390TTCGAOvarian Cancer21720365, 18772890
ENSP00000286201L447VCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000286201Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
FZD7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
WNT11_HUMANFZD7_HUMANligand -> receptorHPMR
WNT5A_HUMANFZD7_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04916Melanogenesis
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma
hsa04310Wnt signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030182neuron differentiationISSbiological_process
GO:0034446substrate adhesion-dependent cell spreadingIEAbiological_process
GO:0005737cytoplasmIBAcellular_component
GO:0038031non-canonical Wnt receptor signaling pathway via JIMPbiological_process
GO:0010812negative regulation of cell-substrate adhesionIEAbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIDAbiological_process
GO:0035567non-canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0007199G-protein coupled receptor signaling pathway couplIBAbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0042327positive regulation of phosphorylationIDAbiological_process
GO:0007420brain developmentIBAbiological_process
GO:0017147Wnt-protein bindingIPImolecular_function
GO:0007223Wnt receptor signaling pathway, calcium modulatingIBAbiological_process
GO:0042813Wnt-activated receptor activityIEAmolecular_function
GO:0032589neuron projection membraneIBAcellular_component
GO:0007409axonogenesisIBAbiological_process
GO:0008406gonad developmentIBAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0010812negative regulation of cell-substrate adhesionIMPbiological_process
GO:0071300cellular response to retinoic acidISSbiological_process
GO:0004888transmembrane signaling receptor activityIEAmolecular_function
GO:0046330positive regulation of JNK cascadeICbiological_process
GO:0035412regulation of catenin import into nucleusIMPbiological_process
GO:0016021integral to membraneTAScellular_component
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0014834satellite cell maintenance involved in skeletal muIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0030165PDZ domain bindingIPImolecular_function
GO:0060070canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0048103somatic stem cell divisionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0019827stem cell maintenanceIMPbiological_process
GO:0060054positive regulation of epithelial cell proliferatiIMPbiological_process
GO:0017147Wnt-protein bindingIEAmolecular_function
GO:0042666negative regulation of ectodermal cell fate specifIMPbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0042813Wnt-activated receptor activityIBAmolecular_function
GO:0060231mesenchymal to epithelial transitionIMPbiological_process
GO:0001944vasculature developmentIBAbiological_process
GO:0045177apical part of cellIBAcellular_component
GO:0006355regulation of transcription, DNA-dependentIMPbiological_process