| UniProt/SwissProt ID: | FRS3_HUMAN |
| Description: | fibroblast growth factor receptor substrate 3 [Source:HGNC Symbol;Acc:16970] |
| Location: | chr6 p21.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S73 | DSNLFsFESGR | IRS | PhosphoSitePlus |
| T166 | PRRLStSSLRH | PhosphoSitePlus | |
| S76 | LFSFEsGRRCQ | IRS | PhosphoSitePlus |
| Y455 | RSSDSyAVIDL | NTRK2 | HPRD |
| S349 | GDDGDsRDGLT | PhosphoSitePlus | |
| Y417 | PRQLNyIQVEL | NTRK2 | HPRD |
| S167 | RRLSTsSLRHP | PhosphoSitePlus | |
| Dephosphorylation site |
| FRS3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000259748 | R93W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000259748 | E214Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000362109 | E214Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000259748 | R52L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000259748 | R121C | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| FRS3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FRS3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NTRK2_HUMAN | FRS3_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| FRS3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005104 | fibroblast growth factor receptor binding | IPI | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0008543 | fibroblast growth factor receptor signaling pathwa | IGI | biological_process |
| GO:0005158 | insulin receptor binding | IEA | molecular_function |