Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	FOXP3_HUMAN
Description:	forkhead box P3 [Source:HGNC Symbol;Acc:6106]
Location:	chrX p11.23
Node attribute:	TF

Phosphorylation site

Position	PhosphoPeptide	Source
S25	PGASPsWRAAP	PhosphoSitePlus
S142	ATGVFsLKARP	PhosphoSitePlus
S13	KPSAPsLALGP	PhosphoSitePlus
S19	LALGPsPGASP	PhosphoSitePlus
T138	PPTTAtGVFSL	PhosphoSitePlus
T115	DAHARtPVLQV	PhosphoSitePlus
S33	AAPKAsDLLGA	PhosphoSitePlus
T44	RGPGGtFQGRD	PhosphoSitePlus

Dephosphorylation site

FOXP3_HUMAN do not have dephosphorylation site.

Mutation site

FOXP3_HUMAN do not have mutation site.

Differential expressed protein

FOXP3_HUMAN is not differential expressed protein.

Hyperphosphorylation site

FOXP3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
FOXP3_HUMAN	CSF2_HUMAN	TF -> target gene	TRANSFAC
FOXP3_HUMAN	TTHY_HUMAN	TF -> target gene	TRANSFAC
FOXP3_HUMAN	IL2_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

FOXP3_HUMAN is not in KEGG pathway.

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0033092	positive regulation of immature T cell proliferati	IEA	biological_process
GO:0003690	double-stranded DNA binding	IBA	molecular_function
GO:0005667	transcription factor complex	IBA	cellular_component
GO:0006357	regulation of transcription from RNA polymerase II	IEA	biological_process
GO:0032914	positive regulation of transforming growth factor	IEA	biological_process
GO:0045077	negative regulation of interferon-gamma biosynthet	IEA	biological_process
GO:0031064	negative regulation of histone deacetylation	IGI	biological_process
GO:0032720	negative regulation of tumor necrosis factor produ	IBA	biological_process
GO:0001816	cytokine production	IEA	biological_process
GO:0032693	negative regulation of interleukin-10 production	IDA	biological_process
GO:0043565	sequence-specific DNA binding	IDA	molecular_function
GO:0035035	histone acetyltransferase binding	IPI	molecular_function
GO:0050710	negative regulation of cytokine secretion	IDA	biological_process
GO:0032713	negative regulation of interleukin-4 production	IDA	biological_process
GO:0032715	negative regulation of interleukin-6 production	IBA	biological_process
GO:0008301	DNA binding, bending	IBA	molecular_function
GO:0002851	positive regulation of peripheral T cell tolerance	IBA	biological_process
GO:0032914	positive regulation of transforming growth factor	IBA	biological_process
GO:0006355	regulation of transcription, DNA-dependent	NAS	biological_process
GO:0009791	post-embryonic development	IBA	biological_process
GO:0035067	negative regulation of histone acetylation	IEA	biological_process
GO:0021549	cerebellum development	IBA	biological_process
GO:0002507	tolerance induction	IEA	biological_process
GO:0002851	positive regulation of peripheral T cell tolerance	IEA	biological_process
GO:0045893	positive regulation of transcription, DNA-dependen	ISS	biological_process
GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory	IEA	biological_process
GO:0002666	positive regulation of T cell tolerance induction	IEA	biological_process
GO:0048302	regulation of isotype switching to IgG isotypes	IBA	biological_process
GO:0007389	pattern specification process	IBA	biological_process
GO:0008270	zinc ion binding	IEA	molecular_function
GO:0043234	protein complex	NAS	cellular_component
GO:0002669	positive regulation of T cell anergy	IEA	biological_process
GO:0046982	protein heterodimerization activity	IBA	molecular_function
GO:0035066	positive regulation of histone acetylation	IEA	biological_process
GO:0033092	positive regulation of immature T cell proliferati	IBA	biological_process
GO:0032715	negative regulation of interleukin-6 production	IEA	biological_process
GO:0042110	T cell activation	IDA	biological_process
GO:0009790	embryo development	IBA	biological_process
GO:0032689	negative regulation of interferon-gamma production	IDA	biological_process
GO:0048294	negative regulation of isotype switching to IgE is	IBA	biological_process
GO:0003700	sequence-specific DNA binding transcription factor	NAS	molecular_function
GO:0045066	regulatory T cell differentiation	IEA	biological_process
GO:0010628	positive regulation of gene expression	IEA	biological_process
GO:0002456	T cell mediated immunity	IEA	biological_process
GO:0002669	positive regulation of T cell anergy	IBA	biological_process
GO:0035067	negative regulation of histone acetylation	IBA	biological_process
GO:0050728	negative regulation of inflammatory response	IEA	biological_process
GO:0035066	positive regulation of histone acetylation	IMP	biological_process
GO:0002677	negative regulation of chronic inflammatory respon	IEA	biological_process
GO:0002513	tolerance induction to self antigen	IBA	biological_process
GO:0050852	T cell receptor signaling pathway	IEA	biological_process
GO:0008285	negative regulation of cell proliferation	IDA	biological_process
GO:0005737	cytoplasm	IEA	cellular_component
GO:0045085	negative regulation of interleukin-2 biosynthetic	IMP	biological_process
GO:0003682	chromatin binding	IBA	molecular_function
GO:0051059	NF-kappaB binding	NAS	molecular_function
GO:0005737	cytoplasm	IBA	cellular_component
GO:0003705	RNA polymerase II distal enhancer sequence-specifi	IEA	molecular_function
GO:0048302	regulation of isotype switching to IgG isotypes	IEA	biological_process
GO:0006338	chromatin remodeling	NAS	biological_process
GO:0032720	negative regulation of tumor necrosis factor produ	IEA	biological_process
GO:0042130	negative regulation of T cell proliferation	IDA	biological_process
GO:0043029	T cell homeostasis	NAS	biological_process
GO:0050777	negative regulation of immune response	IDA	biological_process
GO:0045077	negative regulation of interferon-gamma biosynthet	IBA	biological_process
GO:0045591	positive regulation of regulatory T cell different	IEA	biological_process
GO:0050852	T cell receptor signaling pathway	IBA	biological_process
GO:0009615	response to virus	IEP	biological_process
GO:0042036	negative regulation of cytokine biosynthetic proce	IDA	biological_process
GO:0002262	myeloid cell homeostasis	IEA	biological_process
GO:0032753	positive regulation of interleukin-4 production	IEA	biological_process
GO:0032703	negative regulation of interleukin-2 production	IDA	biological_process
GO:0001782	B cell homeostasis	IBA	biological_process
GO:0002262	myeloid cell homeostasis	IBA	biological_process
GO:0045944	positive regulation of transcription from RNA poly	IMP	biological_process
GO:0048294	negative regulation of isotype switching to IgE is	IEA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0046007	negative regulation of activated T cell proliferat	NAS	biological_process
GO:0043433	negative regulation of sequence-specific DNA bindi	IDA	biological_process
GO:0003714	transcription corepressor activity	IEA	molecular_function
GO:0032714	negative regulation of interleukin-5 production	IBA	biological_process
GO:0045892	negative regulation of transcription, DNA-dependen	IDA	biological_process
GO:0005622	intracellular	IEA	cellular_component
GO:0042826	histone deacetylase binding	IPI	molecular_function
GO:0050672	negative regulation of lymphocyte proliferation	IEA	biological_process
GO:0002725	negative regulation of T cell cytokine production	IDA	biological_process
GO:0003714	transcription corepressor activity	IBA	molecular_function
GO:0005634	nucleus	IDA	cellular_component
GO:0051525	NFAT protein binding	IPI	molecular_function
GO:0001782	B cell homeostasis	IEA	biological_process
GO:0032088	negative regulation of NF-kappaB transcription fac	IDA	biological_process
GO:0042803	protein homodimerization activity	IPI	molecular_function
GO:0032792	negative regulation of CREB transcription factor a	IDA	biological_process
GO:0032831	positive regulation of CD4-positive, CD25-positive	IBA	biological_process
GO:0002637	regulation of immunoglobulin production	IEA	biological_process
GO:0002677	negative regulation of chronic inflammatory respon	IBA	biological_process
GO:0032714	negative regulation of interleukin-5 production	IEA	biological_process
GO:0032831	positive regulation of CD4-positive, CD25-positive	IEA	biological_process
GO:0003705	RNA polymerase II distal enhancer sequence-specifi	IBA	molecular_function
GO:0002513	tolerance induction to self antigen	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network