Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FOXL2_HUMAN
Description:forkhead box L2 [Source:HGNC Symbol;Acc:1092]
Location:chr3 q22.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y215PSPMPyASCQMPhosphoSitePlus
Y258ASYGPyTRVQSPhosphoSitePlus
Y127ERKGNyWTLDPFork_headPhosphoSitePlus
S263YTRVQsMALPPPAK1HPRD; phosphoELM; RegPhos
S323PPGQLsPASPAPhosphoSitePlus
S211LPQPPsPMPYAPhosphoSitePlus
S4__MMAsYPEPEPhosphoSitePlus
T329PASPAtAAPPAPhosphoSitePlus
S326QLSPAsPATAAPhosphoSitePlus
S33EGPPPsPGKGGPhosphoSitePlus; HPRD
Y5_MMASyPEPEDPhosphoSitePlus
Y81TLSGIyQYIIAFork_headPhosphoSitePlus
S238AAGPGsPGAAAPhosphoSitePlus
Y83SGIYQyIIAKFFork_headPhosphoSitePlus
Y91AKFPFyEKNKKFork_headPhosphoSitePlus

Dephosphorylation site
FOXL2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000333188C134WCOSMICOvarian Cancer20693978
ENSP00000333188C134WHPIOvarian Cancer19516027 19956657 22296244 22240241 22248822 21289058 22200085 21188138 21119601 21051974 20693978 22164424
ENSP00000333188E135GCOSMICOvarian Cancer19516027

Differential expressed protein
FOXL2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FOXL2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PKN1_HUMANFOXL2_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
FOXL2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030331estrogen receptor bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005667transcription factor complexIBAcellular_component
GO:0003705RNA polymerase II distal enhancer sequence-specifiIBAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorISSmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0048048embryonic eye morphogenesisIEAbiological_process
GO:0051090regulation of sequence-specific DNA binding transcIBAbiological_process
GO:0030331estrogen receptor bindingIBAmolecular_function
GO:0043065positive regulation of apoptotic processIMPbiological_process
GO:0005634nucleusIDAcellular_component
GO:0048048embryonic eye morphogenesisIBAbiological_process
GO:0030154cell differentiationNASbiological_process
GO:0045944positive regulation of transcription from RNA polyIBAbiological_process
GO:0006917induction of apoptosisIBAbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0031624ubiquitin conjugating enzyme bindingIPImolecular_function
GO:0008301DNA binding, bendingIBAmolecular_function
GO:0043280positive regulation of cysteine-type endopeptidaseIMPbiological_process
GO:0001541ovarian follicle developmentISSbiological_process
GO:0002074extraocular skeletal muscle developmentIMPbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0008134transcription factor bindingIBAmolecular_function
GO:0003677DNA bindingTASmolecular_function
GO:0003690double-stranded DNA bindingIBAmolecular_function
GO:0060026convergent extensionIBAbiological_process
GO:0007389pattern specification processIBAbiological_process
GO:0019101female somatic sex determinationIEAbiological_process
GO:0006309apoptotic DNA fragmentationIMPbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0060014granulosa cell differentiationIEAbiological_process
GO:0042703menstruationIMPbiological_process
GO:0019101female somatic sex determinationIBAbiological_process
GO:0043028cysteine-type endopeptidase regulator activity invIMPmolecular_function