Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FIBA_HUMAN
Description:fibrinogen alpha chain [Source:HGNC Symbol;Acc:3661]
Location:chr4 q31.3
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S578RGKSSsYSKQFHPRD
S549TESRGsESGIFPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S542LGEFVsETESRPhosphoSitePlus
S501DLGTLsGIGTLPhosphoSitePlus
S618HEGTHsTKRGHPKC_groupphosphoELM
S185CRGSCsRALARPhosphoSitePlus
S460TTTRRsCSKTVHPRD
T555ESGIFtNTKESPhosphoSitePlus
S364TWNPGsSERGSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y127NRDNTyNRVSEPhosphoSitePlus
S594YNRGDsTFESKPhosphoSitePlus
S179DIKIRsCRGSCPhosphoSitePlus
S576PSRGKsSSYSKPKC_groupphosphoELM
S297AGSWNsGSSGPPhosphoSitePlus
S22AWTADsGEGDFPhosphoSitePlus; HPRD; phosphoELM
S460TTTRRsCSKTVPKA_groupphosphoELM
T557GIFTNtKESSSPhosphoSitePlus
S618HEGTHsTKRGHHPRD
S578RGKSSsYSKQFPKC_groupphosphoELM
T499AMDLGtLSGIGPhosphoSitePlus
S577SRGKSsSYSKQPKC_groupphosphoELM
S356SPRPGsTGTWNPhosphoSitePlus; HPRD
T126NNRDNtYNRVSPhosphoSitePlus
S561NTKESsSHHPGPhosphoSitePlus
S365WNPGSsERGSAPhosphoSitePlus; HPRD
T505LSGIGtLDGFRPhosphoSitePlus
S609ADEAGsEADHEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y277GGSTSyGTGSEPhosphoSitePlus; HPRD; phosphoELM
T412NPDWGtFEEVSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S576PSRGKsSSYSKHPRD
S524FFDTAsTGKTFPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S577SRGKSsSYSKQHPRD

Dephosphorylation site
FIBA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000306361D680HBIOMARTBreast Cancer21930507, 21930502
ENSP00000306361R35HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000306361W410*COSMICBreast Cancer19812674
ENSP00000306361P565HCOSMICOvarian Cancer21720365
ENSP00000306361L699QCOSMICOvarian Cancer21720365
ENSP00000385981R35HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000306361R847TCOSMICHead and Neck Cancer21798893
ENSP00000306361G840*BIOMARTBreast Cancer21930507, 21930502
ENSP00000306361V541DCOSMICOvarian Cancer21720365
ENSP00000306361D253NCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000306361hepatitis C virusNormal vs. CancertissueUp3.418715028
ENSP00000306361hepatitis B virusNormal vs. CancertissueDown0.0714726492
ENSP00000306361Non-small cell lung carcinomaNormal vs. CancertissueUp18465169
ENSP00000306361Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000306361Hepatocellular CarcinomaNormal vs. CancertissueDown0.0615759316
ENSP00000306361Oral CancerNormal vs. CancertissueUp4.819297561
ENSP00000306361Hepatocellular CarcinomaNormal vs. CancertissueDown18571811
ENSP00000306361breast ductal carcinomaMetastasistissueUp19624269
ENSP00000306361Ovarian CancerNormal vs. CancertissueDown17137333
ENSP00000306361Ovarian CancerNormal vs. CancertissueUp17137333
ENSP00000306361Pancreatic CancerNormal vs. CancertissueDown0.216739137

Hyperphosphorylation site
FIBA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CEBPA_HUMANFIBA_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANFIBA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
FIBA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005938cell cortexIEAcellular_component
GO:0005576extracellular regionNAScellular_component
GO:0030168platelet activationTASbiological_process
GO:0009897external side of plasma membraneIDAcellular_component
GO:0051592response to calcium ionIDAbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0043499eukaryotic cell surface bindingIDAmolecular_function
GO:0051258protein polymerizationIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0005577fibrinogen complexIEAcellular_component
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005615extracellular spaceIDAcellular_component
GO:0007165signal transductionIEAbiological_process
GO:0030674protein binding, bridgingIEAmolecular_function
GO:0031091platelet alpha granuleIDAcellular_component
GO:0007596blood coagulationIEAbiological_process
GO:0005886plasma membraneTAScellular_component


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