| UniProt/SwissProt ID: | FIBA_HUMAN |
| Description: | fibrinogen alpha chain [Source:HGNC Symbol;Acc:3661] |
| Location: | chr4 q31.3 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S578 | RGKSSsYSKQF | HPRD | |
| S549 | TESRGsESGIF | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S542 | LGEFVsETESR | PhosphoSitePlus | |
| S501 | DLGTLsGIGTL | PhosphoSitePlus | |
| S618 | HEGTHsTKRGH | PKC_group | phosphoELM |
| S185 | CRGSCsRALAR | PhosphoSitePlus | |
| S460 | TTTRRsCSKTV | HPRD | |
| T555 | ESGIFtNTKES | PhosphoSitePlus | |
| S364 | TWNPGsSERGS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y127 | NRDNTyNRVSE | PhosphoSitePlus | |
| S594 | YNRGDsTFESK | PhosphoSitePlus | |
| S179 | DIKIRsCRGSC | PhosphoSitePlus | |
| S576 | PSRGKsSSYSK | PKC_group | phosphoELM |
| S297 | AGSWNsGSSGP | PhosphoSitePlus | |
| S22 | AWTADsGEGDF | PhosphoSitePlus; HPRD; phosphoELM | |
| S460 | TTTRRsCSKTV | PKA_group | phosphoELM |
| T557 | GIFTNtKESSS | PhosphoSitePlus | |
| S618 | HEGTHsTKRGH | HPRD | |
| S578 | RGKSSsYSKQF | PKC_group | phosphoELM |
| T499 | AMDLGtLSGIG | PhosphoSitePlus | |
| S577 | SRGKSsSYSKQ | PKC_group | phosphoELM |
| S356 | SPRPGsTGTWN | PhosphoSitePlus; HPRD | |
| T126 | NNRDNtYNRVS | PhosphoSitePlus | |
| S561 | NTKESsSHHPG | PhosphoSitePlus | |
| S365 | WNPGSsERGSA | PhosphoSitePlus; HPRD | |
| T505 | LSGIGtLDGFR | PhosphoSitePlus | |
| S609 | ADEAGsEADHE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y277 | GGSTSyGTGSE | PhosphoSitePlus; HPRD; phosphoELM | |
| T412 | NPDWGtFEEVS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S576 | PSRGKsSSYSK | HPRD | |
| S524 | FFDTAsTGKTF | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S577 | SRGKSsSYSKQ | HPRD | |
| Dephosphorylation site |
| FIBA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000306361 | D680H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000306361 | R35H | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000306361 | W410* | COSMIC | Breast Cancer | 19812674 | ENSP00000306361 | P565H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000306361 | L699Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000385981 | R35H | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000306361 | R847T | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000306361 | G840* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000306361 | V541D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000306361 | D253N | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000306361 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 3.4 | 18715028 | ENSP00000306361 | hepatitis B virus | Normal vs. Cancer | tissue | Down | 0.07 | 14726492 | ENSP00000306361 | Non-small cell lung carcinoma | Normal vs. Cancer | tissue | Up | 18465169 | ENSP00000306361 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000306361 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 0.06 | 15759316 | ENSP00000306361 | Oral Cancer | Normal vs. Cancer | tissue | Up | 4.8 | 19297561 | ENSP00000306361 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 18571811 | ENSP00000306361 | breast ductal carcinoma | Metastasis | tissue | Up | 19624269 | ENSP00000306361 | Ovarian Cancer | Normal vs. Cancer | tissue | Down | 17137333 | ENSP00000306361 | Ovarian Cancer | Normal vs. Cancer | tissue | Up | 17137333 | ENSP00000306361 | Pancreatic Cancer | Normal vs. Cancer | tissue | Down | 0.2 | 16739137 |
| Hyperphosphorylation site |
| FIBA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CEBPA_HUMAN | FIBA_HUMAN | TF -> target gene | TRANSFAC |
| HNF1A_HUMAN | FIBA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| FIBA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005938 | cell cortex | IEA | cellular_component |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0009897 | external side of plasma membrane | IDA | cellular_component |
| GO:0051592 | response to calcium ion | IDA | biological_process |
| GO:0002576 | platelet degranulation | TAS | biological_process |
| GO:0043499 | eukaryotic cell surface binding | IDA | molecular_function |
| GO:0051258 | protein polymerization | IEA | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0005102 | receptor binding | IEA | molecular_function |
| GO:0005577 | fibrinogen complex | IEA | cellular_component |
| GO:0031093 | platelet alpha granule lumen | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0030674 | protein binding, bridging | IEA | molecular_function |
| GO:0031091 | platelet alpha granule | IDA | cellular_component |
| GO:0007596 | blood coagulation | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |