| UniProt/SwissProt ID: | FHOD1_HUMAN |
| Description: | formin homology 2 domain containing 1 [Source:HGNC Symbol;Acc:17905] |
| Location: | chr16 q22.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T823 | RCILAtLLAVG | HPRD | |
| Y963 | LLYLGyTPQAA | FH2 | PhosphoSitePlus |
| Y439 | SERSIyKARFL | PhosphoSitePlus | |
| Y960 | HAFLLyLGYTP | FH2 | PhosphoSitePlus |
| S1131 | RERKRsRGNRK | PhosphoSitePlus; HPRD; RegPhos | |
| T495 | APAARtPQSPA | PhosphoSitePlus; HPRD; phosphoELM | |
| S1131 | RERKRsRGNRK | PKG1/cGK-I | phosphoELM |
| T708 | INIGLtTLPPV | FH2 | PhosphoSitePlus |
| S357 | ERRKPsSEEGK | PhosphoSitePlus | |
| S700 | LDPKRsNAINI | FH2 | PhosphoSitePlus |
| S486 | RQLWDsPETAP | PhosphoSitePlus; HPRD | |
| S367 | KRSRRsLEGGG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T690 | GEGRRtMTTVL | HPRD | |
| S498 | ARTPQsPAPCV | PhosphoSitePlus; HPRD; phosphoELM | |
| S1131 | RERKRsRGNRK | PKG1 | RegPhos |
| S358 | RRKPSsEEGKR | PhosphoSitePlus | |
| S1114 | DLLVQsVTKSS | PhosphoSitePlus | |
| Y176 | AADHNyQSYIL | PhosphoSitePlus | |
| T816 | LVQNAtFRCIL | FH2 | PhosphoSitePlus |
| S874 | QTRPEsSDLYS | FH2 | PhosphoSitePlus |
| T690 | GEGRRtMTTVL | FH2 | PhosphoSitePlus |
| Y878 | ESSDLySEIPA | FH2 | PhosphoSitePlus |
| T1141 | KSLRRtLKSGL | PhosphoSitePlus | |
| T1103 | SLPSDtSDEIM | PhosphoSitePlus | |
| T1010 | RERNKtRGRMI | PhosphoSitePlus | |
| S523 | PLIPAsPKAEP | PhosphoSitePlus; HPRD; phosphoELM | |
| S573 | DIPAPsPPLPL | PhosphoSitePlus; HPRD | |
| S1137 | RGNRKsLRRTL | PhosphoSitePlus | |
| S364 | EEGKRsRRSLE | PhosphoSitePlus | |
| Dephosphorylation site |
| FHOD1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000258201 | P586fs*42 | COSMIC | Breast Cancer | 16959974 | ENSP00000258201 | T251I | COSMIC | Skin Cancer | 21984974 | ENSP00000258201 | P50A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000258201 | S394F | COSMIC | Skin Cancer | 21984974 | ENSP00000258201 | P585fs*43 | COSMIC | Breast Cancer | 17932254 | ENSP00000258201 | E5* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000258201 | E1017K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000258201 | R871Q | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| FHOD1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FHOD1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | FHOD1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| FHOD1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0032059 | bleb | IEA | cellular_component |
| GO:0016043 | cellular component organization | IEA | biological_process |
| GO:0001725 | stress fiber | IDA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
| GO:0003779 | actin binding | IEA | molecular_function |
| GO:0030036 | actin cytoskeleton organization | IEA | biological_process |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0051496 | positive regulation of stress fiber assembly | IDA | biological_process |