Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FHOD1_HUMAN
Description:formin homology 2 domain containing 1 [Source:HGNC Symbol;Acc:17905]
Location:chr16 q22.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T823RCILAtLLAVGHPRD
Y963LLYLGyTPQAAFH2PhosphoSitePlus
Y439SERSIyKARFLPhosphoSitePlus
Y960HAFLLyLGYTPFH2PhosphoSitePlus
S1131RERKRsRGNRKPhosphoSitePlus; HPRD; RegPhos
T495APAARtPQSPAPhosphoSitePlus; HPRD; phosphoELM
S1131RERKRsRGNRKPKG1/cGK-IphosphoELM
T708INIGLtTLPPVFH2PhosphoSitePlus
S357ERRKPsSEEGKPhosphoSitePlus
S700LDPKRsNAINIFH2PhosphoSitePlus
S486RQLWDsPETAPPhosphoSitePlus; HPRD
S367KRSRRsLEGGGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T690GEGRRtMTTVLHPRD
S498ARTPQsPAPCVPhosphoSitePlus; HPRD; phosphoELM
S1131RERKRsRGNRKPKG1RegPhos
S358RRKPSsEEGKRPhosphoSitePlus
S1114DLLVQsVTKSSPhosphoSitePlus
Y176AADHNyQSYILPhosphoSitePlus
T816LVQNAtFRCILFH2PhosphoSitePlus
S874QTRPEsSDLYSFH2PhosphoSitePlus
T690GEGRRtMTTVLFH2PhosphoSitePlus
Y878ESSDLySEIPAFH2PhosphoSitePlus
T1141KSLRRtLKSGLPhosphoSitePlus
T1103SLPSDtSDEIMPhosphoSitePlus
T1010RERNKtRGRMIPhosphoSitePlus
S523PLIPAsPKAEPPhosphoSitePlus; HPRD; phosphoELM
S573DIPAPsPPLPLPhosphoSitePlus; HPRD
S1137RGNRKsLRRTLPhosphoSitePlus
S364EEGKRsRRSLEPhosphoSitePlus

Dephosphorylation site
FHOD1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000258201P586fs*42COSMICBreast Cancer16959974
ENSP00000258201T251ICOSMICSkin Cancer21984974
ENSP00000258201P50ACOSMICOvarian Cancer21720365
ENSP00000258201S394FCOSMICSkin Cancer21984974
ENSP00000258201P585fs*43COSMICBreast Cancer17932254
ENSP00000258201E5*COSMICOvarian Cancer21720365
ENSP00000258201E1017KCOSMICHead and Neck Cancer21798893
ENSP00000258201R871QCOSMICSkin Cancer21984974

Differential expressed protein
FHOD1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FHOD1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANFHOD1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
FHOD1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0032059blebIEAcellular_component
GO:0016043cellular component organizationIEAbiological_process
GO:0001725stress fiberIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0003779actin bindingIEAmolecular_function
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0005488bindingIEAmolecular_function
GO:0051496positive regulation of stress fiber assemblyIDAbiological_process


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