| UniProt/SwissProt ID: | FHL1_HUMAN |
| Description: | four and a half LIM domains 1 [Source:HGNC Symbol;Acc:3702] |
| Location: | chrX q26.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S51 | PIGADsKEVHY | PhosphoSitePlus | |
| Y207 | AVEDQyYCVDC | PhosphoSitePlus | |
| Dephosphorylation site |
| FHL1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000359724 | A168G | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000444815 | A168G | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000443333 | A168G | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000437673 | *310S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000377709 | A168G | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000377710 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 9.6 | 18715028 | ENSP00000377710 | Breast Cancer | Normal vs. Cancer | tissue | Down | 20560667 |
| Hyperphosphorylation site |
| FHL1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TGFR2_HUMAN | FHL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| FHL1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030308 | negative regulation of cell growth | IDA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0009887 | organ morphogenesis | NAS | biological_process |
| GO:0010972 | negative regulation of G2/M transition of mitotic | IDA | biological_process |
| GO:0003674 | molecular_function | ND | molecular_function |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0003254 | regulation of membrane depolarization | IDA | biological_process |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0044325 | ion channel binding | IPI | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0043268 | positive regulation of potassium ion transport | IDA | biological_process |
| GO:2000134 | negative regulation of G1/S transition of mitotic | IDA | biological_process |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:1901016 | regulation of potassium ion transmembrane transpor | IDA | biological_process |
| GO:0007517 | muscle organ development | NAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |