| UniProt/SwissProt ID: | FHIT_HUMAN |
| Description: | fragile histidine triad [Source:HGNC Symbol;Acc:3701] |
| Location: | chrHG1091_PATCH p14. |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y114 | RNDSIyEELQK | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y145 | AALRVyFQ | RegPhos | |
| Y114 | RNDSIyEELQK | SRC | HPRD; RegPhos |
| Dephosphorylation site |
| FHIT_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000418582 | E132Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000417480 | E132Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000417480 | R51H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000342087 | R51H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000417557 | R51H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000418582 | R51H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000342087 | E132Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000417557 | E132Q | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000342087 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 21 hour) | cell line | Down | 0.56 | 15169874 |
| Hyperphosphorylation site |
| FHIT_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SRC_HUMAN | FHIT_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | FHIT_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05223 | Non-small cell lung cancer |
| hsa00230 | Purine metabolism |
| hsa05222 | Small cell lung cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0009117 | nucleotide metabolic process | TAS | biological_process |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0047710 | bis(5'-adenosyl)-triphosphatase activity | IDA | molecular_function |
| GO:0003824 | catalytic activity | TAS | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016787 | hydrolase activity | IEA | molecular_function |