Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FER_HUMAN
Description:fer (fps/fes related) tyrosine kinase [Source:HGNC Symbol;Acc:3655]
Location:chr5 q21.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S587LKDKTsVAVKTPkinase_TyrPhosphoSitePlus
Y714EDGGVySSSGLPkinase_TyrPhosphoSitePlus; SysPTM
Y200HQNQYyDITLPPhosphoSitePlus
S715DGGVYsSSGLKPkinase_TyrPhosphoSitePlus
Y199LHQNQyYDITLPhosphoSitePlus
Y401PPPVVnYEEDAHPRD
Y714EDGGVySSSGLphosphoELM; RegPhos; SysPTM
S113QQVKKsYIGVHPhosphoSitePlus
Y497YVLSVySDGQRSH2PhosphoSitePlus
Y492GKPGEyVLSVYSH2PhosphoSitePlus
S498VLSVYsDGQRRSH2PhosphoSitePlus
S434AGIIRsPKSALFERHPRD; SysPTM
T592SVAVKtCKEDLPkinase_TyrPhosphoSitePlus
T27LRLLEtVKKFMFCHPhosphoSitePlus
T410DARSVtSMERKPhosphoSitePlus; HPRD
S70SNVSKsWLLMIFCHPhosphoSitePlus
S716GGVYSsSGLKQPkinase_TyrPhosphoSitePlus
Y402PPVVNyEEDARFERHPRD; SysPTM
Y734PEALNyGRYSSPkinase_TyrPhosphoSitePlus
Y402PPVVNyEEDARPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S411ARSVTsMERKEPhosphoSitePlus; HPRD; SysPTM
Y114QVKKSyIGVHQPhosphoSitePlus
S423LSKFEsIRHSIPhosphoSitePlus
Y714EDGGVySSSGLautocatalysisRegPhos; SysPTM
Y615KILKQyDHPNIPkinase_TyrPhosphoSitePlus
T586TLKDKtSVAVKPkinase_TyrPhosphoSitePlus
Y714EDGGVySSSGLFERHPRD; RegPhos; SysPTM
S434AGIIRsPKSALPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
Y229GIFDEySQITSPhosphoSitePlus

Dephosphorylation site
FER_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000281092W460CHPISmall cell lung carcinoma17344846
ENSP00000281092E404QGreenman2007, HPIOvarian Cancer17344846, 18428421
ENSP00000281092S44CBIOMARTBreast Cancer21930507, 21930502
ENSP00000281092W460CGreenman2007Lung Cancer17344846, 18428421
ENSP00000281092A728SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
FER_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FER_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FER_HUMANSRC8_HUMANkinase -> substrateHPRD; RegPhos
FER_HUMANFER_HUMANkinase -> substrateHPRD; RegPhos
FER_HUMANPLAK_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANFER_HUMANkinase -> substrateRegPhos
FER_HUMANCTNB1_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04520Adherens junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031532actin cytoskeleton reorganizationIEAbiological_process
GO:0030054cell junctionIDAcellular_component
GO:0042058regulation of epidermal growth factor receptor sigIMPbiological_process
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0017137Rab GTPase bindingIEAmolecular_function
GO:0038095Fc-epsilon receptor signaling pathwayIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0048008platelet-derived growth factor receptor signaling ISSbiological_process
GO:0008289lipid bindingIDAmolecular_function
GO:0008092cytoskeletal protein bindingIEAmolecular_function
GO:0031234extrinsic to internal side of plasma membraneIDAcellular_component
GO:0007165signal transductionIEAbiological_process
GO:0042503tyrosine phosphorylation of Stat3 proteinIDAbiological_process
GO:0036006cellular response to macrophage colony-stimulatingIMPbiological_process
GO:0006935chemotaxisIEAbiological_process
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0036119response to platelet-derived growth factor stimuluISSbiological_process
GO:0032496response to lipopolysaccharideISSbiological_process
GO:0036119response to platelet-derived growth factor stimuluIEAbiological_process
GO:0044331cell-cell adhesion mediated by cadherinISSbiological_process
GO:0030027lamellipodiumIDAcellular_component
GO:0032869cellular response to insulin stimulusIEAbiological_process
GO:0050839cell adhesion molecule bindingIEAmolecular_function
GO:0010591regulation of lamellipodium assemblyIDAbiological_process
GO:0038109Kit signaling pathwayIEAbiological_process
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0032869cellular response to insulin stimulusISSbiological_process
GO:0048008platelet-derived growth factor receptor signaling IEAbiological_process
GO:0033007negative regulation of mast cell activation involvIEAbiological_process
GO:0035556intracellular signal transductionTASbiological_process
GO:0035426extracellular matrix-cell signalingISSbiological_process
GO:0034614cellular response to reactive oxygen speciesIEAbiological_process
GO:0038028insulin receptor signaling pathway via phosphatidyIEAbiological_process
GO:0030838positive regulation of actin filament polymerizatiIMPbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayISSbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0045296cadherin bindingIEAmolecular_function
GO:0008157protein phosphatase 1 bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0005154epidermal growth factor receptor bindingIDAmolecular_function
GO:0004715non-membrane spanning protein tyrosine kinase actiIDAmolecular_function
GO:0010762regulation of fibroblast migrationIEAbiological_process
GO:0034446substrate adhesion-dependent cell spreadingIEAbiological_process
GO:0045295gamma-catenin bindingIEAmolecular_function
GO:0000226microtubule cytoskeleton organizationIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0007155cell adhesionIEAbiological_process
GO:0001932regulation of protein phosphorylationISSbiological_process
GO:0050904diapedesisIEAbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0034614cellular response to reactive oxygen speciesISSbiological_process
GO:0005634nucleusIDAcellular_component
GO:0046777protein autophosphorylationIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0034446substrate adhesion-dependent cell spreadingISSbiological_process
GO:0001932regulation of protein phosphorylationIEAbiological_process
GO:0031532actin cytoskeleton reorganizationISSbiological_process
GO:0000790nuclear chromatinIDAcellular_component
GO:0044331cell-cell adhesion mediated by cadherinIEAbiological_process
GO:0035426extracellular matrix-cell signalingIEAbiological_process
GO:0000278mitotic cell cycleIMPbiological_process
GO:0005938cell cortexIEAcellular_component
GO:0038028insulin receptor signaling pathway via phosphatidyISSbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0050904diapedesisISSbiological_process
GO:0070102interleukin-6-mediated signaling pathwayIMPbiological_process
GO:0019221cytokine-mediated signaling pathwayIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0015629actin cytoskeletonIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0033007negative regulation of mast cell activation involvISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0008283cell proliferationIMPbiological_process
GO:0038109Kit signaling pathwayISSbiological_process
GO:0003779actin bindingIEAmolecular_function