Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FANCA_HUMAN
Description:Fanconi anemia, complementation group A [Source:HGNC Symbol;Acc:3582]
Location:chr16 q24.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1149RSRDPsLMVDFAKT1HPRD; RegPhos
S357HPLLTsLYRRLPhosphoSitePlus
S858RDTLCsCLSPGHPRD; RegPhos
Y488FESPRyLQVHIPhosphoSitePlus
S1149RSRDPsLMVDFAKT_groupRegPhos
S309GHTLGsVISTDPhosphoSitePlus
S1301EKRKIsWLALFFanconi_APhosphoSitePlus
S1149RSRDPsLMVDFPKB_groupphosphoELM
S1449PDADLsQEPHLPhosphoSitePlus; RegPhos; SysPTM
T351WSFARtHPLLTPhosphoSitePlus
S421AQAFEsCQLDSPhosphoSitePlus
T1309ALFQLtESDLRFanconi_APhosphoSitePlus
T329LTQILtHSPVLPhosphoSitePlus
S337PVLKAsDAVQMPhosphoSitePlus
S1208GRQFAsDFLSPPhosphoSitePlus
T323RFFSHtLTQILPhosphoSitePlus
S850LCKFSsQSRDTHPRD; RegPhos
S849SLCKFsSQSRDHPRD; RegPhos
S303WFGVFsGHTLGPhosphoSitePlus
S1449PDADLsQEPHHPRD; phosphoELM; SysPTM
S458KASFGsTRGYHPhosphoSitePlus
S1149RSRDPsLMVDFPhosphoSitePlus

Dephosphorylation site
FANCA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000373952S1094GCOSMICOvarian Cancer21720365
ENSP00000373952P500ACOSMICOvarian Cancer21720365
ENSP00000373952M160ICOSMICBreast Cancer20668451
ENSP00000373952W932LCOSMICBreast Cancer17932254
ENSP00000373952T567ICOSMICSkin Cancer21984974

Differential expressed protein
FANCA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FANCA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANFANCA_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANFANCA_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03460Fanconi anemia pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007140male meiosisIEAbiological_process
GO:0006281DNA repairTASbiological_process
GO:0043240Fanconi anaemia nuclear complexIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0008584male gonad developmentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0008585female gonad developmentIEAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006461protein complex assemblyTASbiological_process


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