Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FA8_HUMAN
Description:coagulation factor VIII, procoagulant component [Source:HGNC Symbol;Acc:3546]
Location:chrX q28
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1947GYIMDtLPGLVCu-oxidase_2PhosphoSitePlus
S977MNSQEsSWGKNPhosphoSitePlus
T1758VFQEFtDGSFTHPRD
T1022LKTNKtSNNSAPhosphoSitePlus
S1413PIAKVsSFPSIPhosphoSitePlus
T1576ESSAKtPSKLLPhosphoSitePlus
S1405PQANRsPLPIAPhosphoSitePlus
S1023KTNKTsNNSATPhosphoSitePlus
T1028SNNSAtNRKTHPhosphoSitePlus
S1084RLNHMsNKTTSPhosphoSitePlus
S1390TQSPLsDCLTRPhosphoSitePlus
T1284RTKKHtAHFSKPhosphoSitePlus
T1424RPIYLtRVLFQPhosphoSitePlus
S1026KTSNNsATNRKPhosphoSitePlus
T1930QMEDPtFKENYCu-oxidase_2PhosphoSitePlus
S1761EFTDGsFTQPLHPRD
Y1990RKKEEyKMALYCu-oxidase_2PhosphoSitePlus
S1578SAKTPsKLLDPPhosphoSitePlus
T1763TDGSFtQPLYRHPRD

Dephosphorylation site
FA8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353393R814*COSMICIntestines Cancer17932254
ENSP00000353393P1564SCOSMICSkin Cancer21984974
ENSP00000353393S1463PCOSMICPancreatic Cancer
ENSP00000353393S1463PCOSMICPancreatic Cancer
ENSP00000353393W87RCOSMICOvarian Cancer21720365
ENSP00000353393Y365CBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000353393A1262ECOSMICHead and Neck Cancer21798893
ENSP00000353393S1136FCOSMICSkin Cancer21984974
ENSP00000353393R1715*COSMICOvarian Cancer21720365
ENSP00000353393P1564SCOSMICSkin Cancer21984974
ENSP00000353393W87RCOSMICOvarian Cancer21720365
ENSP00000353393E1345VCOSMICHead and Neck Cancer21798893
ENSP00000353393A394DCOSMICHepatocellular Carcinoma21822264
ENSP00000353393R437QCOSMICPancreatic Cancer
ENSP00000353393A394DCOSMICHepatocellular Carcinoma21822264
ENSP00000353393R1715*COSMICOvarian Cancer21720365
ENSP00000353393S577YCOSMICOvarian Cancer21720365
ENSP00000353393E464KBIOMARTBreast Cancer21930507, 21930502
ENSP00000353393A2227PCOSMICOvarian Cancer21720365
ENSP00000353393A2207ECOSMICIntestines Cancer17932254
ENSP00000353393S1136FCOSMICSkin Cancer21984974
ENSP00000353393E1345VCOSMICHead and Neck Cancer21798893
ENSP00000353393A2227PCOSMICOvarian Cancer21720365
ENSP00000353393G582ECOSMICHead and Neck Cancer
ENSP00000353393A1262ECOSMICHead and Neck Cancer21798893
ENSP00000353393S577YCOSMICOvarian Cancer21720365
ENSP00000353393K1612NCOSMICHead and Neck Cancer21798893
ENSP00000353393R437QCOSMICPancreatic Cancer
ENSP00000353393K1612NCOSMICHead and Neck Cancer21798893

Differential expressed protein
FA8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FA8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FA8_HUMANLRP1_HUMANligand -> receptorHPMR
HNF1A_HUMANFA8_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04610Complement and coagulation cascades

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0007597blood coagulation, intrinsic pathwayTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0005576extracellular regionNAScellular_component
GO:0006953acute-phase responseIEAbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0005507copper ion bindingIEAmolecular_function
GO:0016491oxidoreductase activityIEAmolecular_function
GO:0030168platelet activationTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005615extracellular spaceIEAcellular_component
GO:0005515protein bindingIPImolecular_function


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