| UniProt/SwissProt ID: | FA8_HUMAN |
| Description: | coagulation factor VIII, procoagulant component [Source:HGNC Symbol;Acc:3546] |
| Location: | chrX q28 |
| Node attribute: | ligand; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T1947 | GYIMDtLPGLV | Cu-oxidase_2 | PhosphoSitePlus |
| S977 | MNSQEsSWGKN | PhosphoSitePlus | |
| T1758 | VFQEFtDGSFT | HPRD | |
| T1022 | LKTNKtSNNSA | PhosphoSitePlus | |
| S1413 | PIAKVsSFPSI | PhosphoSitePlus | |
| T1576 | ESSAKtPSKLL | PhosphoSitePlus | |
| S1405 | PQANRsPLPIA | PhosphoSitePlus | |
| S1023 | KTNKTsNNSAT | PhosphoSitePlus | |
| T1028 | SNNSAtNRKTH | PhosphoSitePlus | |
| S1084 | RLNHMsNKTTS | PhosphoSitePlus | |
| S1390 | TQSPLsDCLTR | PhosphoSitePlus | |
| T1284 | RTKKHtAHFSK | PhosphoSitePlus | |
| T1424 | RPIYLtRVLFQ | PhosphoSitePlus | |
| S1026 | KTSNNsATNRK | PhosphoSitePlus | |
| T1930 | QMEDPtFKENY | Cu-oxidase_2 | PhosphoSitePlus |
| S1761 | EFTDGsFTQPL | HPRD | |
| Y1990 | RKKEEyKMALY | Cu-oxidase_2 | PhosphoSitePlus |
| S1578 | SAKTPsKLLDP | PhosphoSitePlus | |
| T1763 | TDGSFtQPLYR | HPRD | |
| Dephosphorylation site |
| FA8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000353393 | R814* | COSMIC | Intestines Cancer | 17932254 | ENSP00000353393 | P1564S | COSMIC | Skin Cancer | 21984974 | ENSP00000353393 | S1463P | COSMIC | Pancreatic Cancer | ENSP00000353393 | S1463P | COSMIC | Pancreatic Cancer | ENSP00000353393 | W87R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353393 | Y365C | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000353393 | A1262E | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000353393 | S1136F | COSMIC | Skin Cancer | 21984974 | ENSP00000353393 | R1715* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353393 | P1564S | COSMIC | Skin Cancer | 21984974 | ENSP00000353393 | W87R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353393 | E1345V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000353393 | A394D | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000353393 | R437Q | COSMIC | Pancreatic Cancer | ENSP00000353393 | A394D | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000353393 | R1715* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353393 | S577Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353393 | E464K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000353393 | A2227P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353393 | A2207E | COSMIC | Intestines Cancer | 17932254 | ENSP00000353393 | S1136F | COSMIC | Skin Cancer | 21984974 | ENSP00000353393 | E1345V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000353393 | A2227P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353393 | G582E | COSMIC | Head and Neck Cancer | ENSP00000353393 | A1262E | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000353393 | S577Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353393 | K1612N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000353393 | R437Q | COSMIC | Pancreatic Cancer | ENSP00000353393 | K1612N | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| FA8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FA8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FA8_HUMAN | LRP1_HUMAN | ligand -> receptor | HPMR |
| HNF1A_HUMAN | FA8_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04610 | Complement and coagulation cascades |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0031093 | platelet alpha granule lumen | TAS | cellular_component |
| GO:0007597 | blood coagulation, intrinsic pathway | TAS | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0002576 | platelet degranulation | TAS | biological_process |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0006953 | acute-phase response | IEA | biological_process |
| GO:0055114 | oxidation-reduction process | IEA | biological_process |
| GO:0005507 | copper ion binding | IEA | molecular_function |
| GO:0016491 | oxidoreductase activity | IEA | molecular_function |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |