Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FA5_HUMAN
Description:coagulation factor V (proaccelerin, labile factor) [Source:HGNC Symbol;Acc:3542]
Location:chr1 q24.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S937LLLKQsNSSKIPhosphoSitePlus
T1627KYLDStFTKRDPhosphoSitePlus
T706STVMAtRKMHDPhosphoSitePlus
T1058SEAYNtFSERRPhosphoSitePlus; HPRD
S528LLICKsRSLDRPhosphoSitePlus
S692DDDEDsYEIFECK2a1RegPhos
S955ASEKGsYEIIQPhosphoSitePlus; HPRD
S720PEDEEsDADYDCK2_alphaphosphoELM
S284NHHKVsAITLVPhosphoSitePlus
S692DDDEDsYEIFECK2_groupphosphoELM; RegPhos
S692DDDEDsYEIFECSNK2A1HPRD
S1626RKYLDsTFTKRPhosphoSitePlus
S1150SHRSSsPELSEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y323AGMQAyIDIKNPhosphoSitePlus
Y2149LSSEMyVKSYTF5_F8_type_CPhosphoSitePlus
S692DDDEDsYEIFECK2a1-rsRegPhos
S517MRDIAsGLIGLPhosphoSitePlus
S720PEDEEsDADYDPhosphoSitePlus; phosphoELM
S1690TYEDDsPEWFKPhosphoSitePlus
T1629LDSTFtKRDPRPhosphoSitePlus
T640KRHEDtLTLFPPhosphoSitePlus
S2198NPPIIsRFIRVF5_F8_type_CPhosphoSitePlus
S1053FHPLRsEAYNTPhosphoSitePlus; HPRD
Y693DDEDSyEIFEPPhosphoSitePlus; HPRD
S1676HAHGLsYEKSSPhosphoSitePlus
T1047PLSPRtFHPLRPhosphoSitePlus; HPRD
S1148DPSHRsSSPELPhosphoSitePlus; HPRD
T1685SSEGKtYEDDSPhosphoSitePlus
S2158YTIHYsEQGVEF5_F8_type_CPhosphoSitePlus
S720PEDEEsDADYDCK2a1(CK2 alphaRegPhos
Y1623VVFRKyLDSTFPhosphoSitePlus
Y1056LRSEAyNTFSEPhosphoSitePlus; HPRD

Dephosphorylation site
FA5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356771G196ECOSMICMelanoma21499247
ENSP00000356771I339RCOSMICHead and Neck Cancer21798893
ENSP00000356771M413VCOSMICHead and Neck Cancer21798893
ENSP00000356771R647CCOSMICHead and Neck Cancer21798893
ENSP00000356771L523ICOSMICOvarian Cancer21720365
ENSP00000356770P932SBIOMARTBreast Cancer21930507, 21930502
ENSP00000356771Y2149CCOSMICOvarian Cancer21720365
ENSP00000356771V434MCOSMICCentral Nervous System Neoplasms18772396
ENSP00000356771S775ASjoblom2006, COSMICIntestines Cancer16959974
ENSP00000356771P699QCOSMICHead and Neck Cancer21798893
ENSP00000356771P927SBIOMARTBreast Cancer21930507, 21930502
ENSP00000356771S775AHPIColorectal Cancer16959974
ENSP00000356771E156KCOSMICHead and Neck Cancer21798893
ENSP00000356771I2196FCOSMICOvarian Cancer21720365

Differential expressed protein
FA5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FA5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANFA5_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04610Complement and coagulation cascades

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneTAScellular_component
GO:0031091platelet alpha granuleIEAcellular_component
GO:0008015blood circulationIEAbiological_process
GO:0005576extracellular regionNAScellular_component
GO:0030168platelet activationTASbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0007596blood coagulationIEAbiological_process
GO:0005507copper ion bindingIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0007155cell adhesionIEAbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0005515protein bindingIPImolecular_function


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