| UniProt/SwissProt ID: | FA5_HUMAN |
| Description: | coagulation factor V (proaccelerin, labile factor) [Source:HGNC Symbol;Acc:3542] |
| Location: | chr1 q24.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S937 | LLLKQsNSSKI | PhosphoSitePlus | |
| T1627 | KYLDStFTKRD | PhosphoSitePlus | |
| T706 | STVMAtRKMHD | PhosphoSitePlus | |
| T1058 | SEAYNtFSERR | PhosphoSitePlus; HPRD | |
| S528 | LLICKsRSLDR | PhosphoSitePlus | |
| S692 | DDDEDsYEIFE | CK2a1 | RegPhos |
| S955 | ASEKGsYEIIQ | PhosphoSitePlus; HPRD | |
| S720 | PEDEEsDADYD | CK2_alpha | phosphoELM |
| S284 | NHHKVsAITLV | PhosphoSitePlus | |
| S692 | DDDEDsYEIFE | CK2_group | phosphoELM; RegPhos |
| S692 | DDDEDsYEIFE | CSNK2A1 | HPRD |
| S1626 | RKYLDsTFTKR | PhosphoSitePlus | |
| S1150 | SHRSSsPELSE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y323 | AGMQAyIDIKN | PhosphoSitePlus | |
| Y2149 | LSSEMyVKSYT | F5_F8_type_C | PhosphoSitePlus |
| S692 | DDDEDsYEIFE | CK2a1-rs | RegPhos |
| S517 | MRDIAsGLIGL | PhosphoSitePlus | |
| S720 | PEDEEsDADYD | PhosphoSitePlus; phosphoELM | |
| S1690 | TYEDDsPEWFK | PhosphoSitePlus | |
| T1629 | LDSTFtKRDPR | PhosphoSitePlus | |
| T640 | KRHEDtLTLFP | PhosphoSitePlus | |
| S2198 | NPPIIsRFIRV | F5_F8_type_C | PhosphoSitePlus |
| S1053 | FHPLRsEAYNT | PhosphoSitePlus; HPRD | |
| Y693 | DDEDSyEIFEP | PhosphoSitePlus; HPRD | |
| S1676 | HAHGLsYEKSS | PhosphoSitePlus | |
| T1047 | PLSPRtFHPLR | PhosphoSitePlus; HPRD | |
| S1148 | DPSHRsSSPEL | PhosphoSitePlus; HPRD | |
| T1685 | SSEGKtYEDDS | PhosphoSitePlus | |
| S2158 | YTIHYsEQGVE | F5_F8_type_C | PhosphoSitePlus |
| S720 | PEDEEsDADYD | CK2a1(CK2 alpha | RegPhos |
| Y1623 | VVFRKyLDSTF | PhosphoSitePlus | |
| Y1056 | LRSEAyNTFSE | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| FA5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356771 | G196E | COSMIC | Melanoma | 21499247 | ENSP00000356771 | I339R | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000356771 | M413V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000356771 | R647C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000356771 | L523I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000356770 | P932S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356771 | Y2149C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000356771 | V434M | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000356771 | S775A | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000356771 | P699Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000356771 | P927S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356771 | S775A | HPI | Colorectal Cancer | 16959974 | ENSP00000356771 | E156K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000356771 | I2196F | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| FA5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FA5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK21_HUMAN | FA5_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04610 | Complement and coagulation cascades |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0031091 | platelet alpha granule | IEA | cellular_component |
| GO:0008015 | blood circulation | IEA | biological_process |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0007596 | blood coagulation | IEA | biological_process |
| GO:0005507 | copper ion binding | IEA | molecular_function |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0031093 | platelet alpha granule lumen | TAS | cellular_component |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0002576 | platelet degranulation | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |