Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EZH2_HUMAN
Description:enhancer of zeste homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:3527]
Location:chr7 q36.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T421NSRCQtPIKMKHPRD
S690FDYRYsQADALHPRD
S327NSSRPsTPTINHPRD
S8QTGKKsEKGPVPhosphoSitePlus
S220PRKFPsDKIFEPhosphoSitePlus
T300FAAALtAERIKHPRD
Y696VNPNCyAKVMMSETPhosphoSitePlus
T328SSRPStPTINVHPRD
S405KKDETsSSSEAPhosphoSitePlus
S413ETSSSsEANSRHPRD
S369ETSSSsEANSRHPRD
S375INVLEsKDTDSPhosphoSitePlus
S363LPNNSsRPSTPPhosphoSitePlus
T372SSRPStPTINVHPRD
T487AEDVDtPPRKKPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S371NSSRPsTPTINHPRD
S412SSEANsRCQTPPhosphoSitePlus
S21RKRVKsEYMRLAKT1HPRD; RegPhos
T339FAAALtAERIKPhosphoSitePlus; phosphoELM
T345AERIKtPPKRPPhosphoSitePlus
S366NSSRPsTPTINPhosphoSitePlus; phosphoELM
S385SKDTDsDREAGHPRD
Y23RVKSEyMRLRQPhosphoSitePlus
S734FDYRYsQADALHPRD
T460ARLIGtKTCRQPhosphoSitePlus
T416NSRCQtPIKMKPhosphoSitePlus
T369RPSTPtINVLEPhosphoSitePlus
T377NSRCQtPIKMKHPRD
S341SKDTDsDREAGHPRD
S380SKDTDsDREAGPhosphoSitePlus; phosphoELM; RegPhos
S417SSEANsRCQTPHPRD
S21RKRVKsEYMRLPhosphoSitePlus; phosphoELM; RegPhos
T344FAAALtAERIKHPRD
T492AEDVDtPPRKKHPRD
S362RLPNNsSRPSTPhosphoSitePlus
S373SSEANsRCQTPHPRD
S406KDETSsSSEANPhosphoSitePlus
T448AEDVDtPPRKKHPRD
T367SSRPStPTINVPhosphoSitePlus; phosphoELM

Dephosphorylation site
EZH2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000320147R566HCOSMICLymphoma21921040
ENSP00000320147R207*COSMICLymphoma20601953
ENSP00000320147L674VCOSMICLymphoma20601954
ENSP00000320147R63*COSMICLymphoma21921040
ENSP00000320147Q328*COSMICLymphoma20601953
ENSP00000320147A656VCOSMICLymphoma20601953
ENSP00000320147I150TCOSMICLymphoma21921040
ENSP00000320147N693ICOSMICLymphoma20601953
ENSP00000320147P132SCOSMICLymphoma21921040
ENSP00000320147H297RCOSMICLymphoma20601953
ENSP00000320147S538LCOSMICHead and Neck Cancer21798893
ENSP00000320147R25*COSMICLymphoma20601953
ENSP00000320147R684CCOSMICLymphoma20601953
ENSP00000320147D677HCOSMICLymphoma21921040
ENSP00000320147E317*COSMICLymphoma20601953
ENSP00000320147E726VCOSMICLymphoma21921040
ENSP00000320147Q553*COSMICLymphoma21921040
ENSP00000320147P636LCOSMICLymphoma21275949
ENSP00000320147N675KCOSMICLymphoma20601954
ENSP00000320147R288QCOSMICLymphoma21921040
ENSP00000320147V704LCOSMICLymphoma21921040
ENSP00000320147G159RCOSMICLymphoma21390130
ENSP00000320147Q62*COSMICLymphoma20601953
ENSP00000320147Y646NCOSMICSkin Cancer21984974
ENSP00000320147Y244DCOSMICLymphoma20601953
ENSP00000320147R561HCOSMICLymphoma21921040
ENSP00000320147I713TCOSMICLymphoma20601953
ENSP00000320147N640KCOSMICLymphoma20081860
ENSP00000320147W60*COSMICLymphoma21921040
ENSP00000320147Y181CCOSMICHead and Neck Cancer21798893
ENSP00000320147C571YCOSMICLymphoma20601953
ENSP00000320147I264RCOSMICHead and Neck Cancer21798893
ENSP00000320147L252VCOSMICLymphoma20601953
ENSP00000320147Q58*COSMICLymphoma20601953
ENSP00000320147K243QCOSMICLymphoma20601953
ENSP00000320147Y731DCOSMICLymphoma20601953
ENSP00000320147A345TCOSMICLymphoma20601953
ENSP00000320147D664ACOSMICLymphoma21909114
ENSP00000320147R509GCOSMICLymphoma20601953
ENSP00000320147C576WCOSMICLymphoma20601953
ENSP00000320147N322SCOSMICLymphoma21921040
ENSP00000320147F145SCOSMICLymphoma21921040
ENSP00000320147R690HCOSMICLymphoma21921040
ENSP00000320147D192NCOSMICLymphoma20601953
ENSP00000320147G135RCOSMICLymphoma21921040
ENSP00000320147A255TCOSMICLymphoma20601953
ENSP00000320147E249KCOSMICLymphoma20601953
ENSP00000320147Y733*COSMICLymphoma21921040
ENSP00000320147V679MCOSMICLymphoma21921040
ENSP00000320147G660RCOSMICLymphoma20601953
ENSP00000320147H694YCOSMICLymphoma20724984
ENSP00000320147T573ICOSMICLymphoma21921040
ENSP00000320147L149QCOSMICLymphoma21921040

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000419856Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineUp1.615169874

Hyperphosphorylation site
EZH2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANEZH2_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANEZH2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
EZH2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000084S phase of mitotic cell cycleIEAbiological_process
GO:0045605negative regulation of epidermal cell differentiatIEAbiological_process
GO:0048387negative regulation of retinoic acid receptor signIMPbiological_process
GO:0042054histone methyltransferase activityIDAmolecular_function
GO:0051154negative regulation of striated muscle cell differIEAbiological_process
GO:0045120pronucleusIEAcellular_component
GO:0018024histone-lysine N-methyltransferase activityIEAmolecular_function
GO:0016571histone methylationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0034244negative regulation of transcription elongation frIEAbiological_process
GO:0042054histone methyltransferase activityIEAmolecular_function
GO:0021695cerebellar cortex developmentIEAbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0035098ESC/E(Z) complexIDAcellular_component
GO:0050767regulation of neurogenesisIEAbiological_process
GO:0006325chromatin organizationTASbiological_process
GO:0006355regulation of transcription, DNA-dependentTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0014013regulation of gliogenesisIEAbiological_process
GO:0070734histone H3-K27 methylationIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0035098ESC/E(Z) complexIEAcellular_component
GO:0070314G1 to G0 transitionIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0001047core promoter bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0001932regulation of protein phosphorylationIEAbiological_process