| UniProt/SwissProt ID: | EZH1_HUMAN |
| Description: | enhancer of zeste homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:3526] |
| Location: | chr17 q21.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y697 | VNPNCyAKVVM | SET | PhosphoSitePlus |
| Y319 | ATPNVyKRKNK | PhosphoSitePlus | |
| S490 | ELMNPsQKKKR | PhosphoSitePlus | |
| Y305 | RRCFKyDCFLH | PhosphoSitePlus | |
| Dephosphorylation site |
| EZH1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000404658 | K322R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000404658 | A375T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000404658 | E721K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000407869 | A335T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000404071 | A236T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000404658 | E722V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000404658 | I151F | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| EZH1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| EZH1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| VRK3_HUMAN | EZH1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| EZH1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0070734 | histone H3-K27 methylation | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0046976 | histone methyltransferase activity (H3-K27 specifi | IEA | molecular_function |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0035098 | ESC/E(Z) complex | IDA | cellular_component |
| GO:0009653 | anatomical structure morphogenesis | TAS | biological_process |
| GO:0018024 | histone-lysine N-methyltransferase activity | IEA | molecular_function |
| GO:0035098 | ESC/E(Z) complex | IEA | cellular_component |