| UniProt/SwissProt ID: | EWS_HUMAN |
| Description: | Ewing sarcoma breakpoint region 1 [Source:HGNC Symbol;Acc:3508] |
| Location: | chr22 q12.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y417 | DATVSyEDPPT | RRM_6 | PhosphoSitePlus |
| Y656 | RRDRPy_____ | PhosphoSitePlus | |
| S371 | QGLNDsVTLDD | HPRD | |
| S371 | QGLNDsVTLDD | RRM_6 | PhosphoSitePlus |
| S266 | YGQQSsFRQDH | PhosphoSitePlus | |
| S266 | YGQQSsFRQDH | PKCa | RegPhos |
| S376 | QGLNDsVTLDD | HPRD | |
| S266 | YGQQSsFRQDH | PRKCA | HPRD |
| Y278 | SSMGVyGQESG | PhosphoSitePlus | |
| S266 | YGQQSsFRQDH | PKC_group | phosphoELM; RegPhos |
| T79 | PTGYTtPTAPQ | PhosphoSitePlus | |
| S358 | DPDEDsDNSAI | HPRD | |
| Dephosphorylation site |
| EWS_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000381031 | R494* | COSMIC | Lung Cancer | 20668451 | ENSP00000381031 | G501A | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000381031 | Q395* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000400142 | Q400* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000385726 | G245V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000381031 | G245V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000385726 | T413A | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000381031 | T414A | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000381031 | Non-small cell lung carcinoma | Treatment (none vs CIGB-300 treatment) | cell line | Down | 0.4 | 20804217 |
| Hyperphosphorylation site |
| EWS_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | EWS_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05202 | Transcriptional misregulation in cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005516 | calmodulin binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |