Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EWS_HUMAN
Description:Ewing sarcoma breakpoint region 1 [Source:HGNC Symbol;Acc:3508]
Location:chr22 q12.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y417DATVSyEDPPTRRM_6PhosphoSitePlus
Y656RRDRPy_____PhosphoSitePlus
S371QGLNDsVTLDDHPRD
S371QGLNDsVTLDDRRM_6PhosphoSitePlus
S266YGQQSsFRQDHPhosphoSitePlus
S266YGQQSsFRQDHPKCaRegPhos
S376QGLNDsVTLDDHPRD
S266YGQQSsFRQDHPRKCAHPRD
Y278SSMGVyGQESGPhosphoSitePlus
S266YGQQSsFRQDHPKC_groupphosphoELM; RegPhos
T79PTGYTtPTAPQPhosphoSitePlus
S358DPDEDsDNSAIHPRD

Dephosphorylation site
EWS_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000381031R494*COSMICLung Cancer20668451
ENSP00000381031G501ACOSMICHepatocellular Carcinoma21822264
ENSP00000381031Q395*BIOMARTBreast Cancer21930507, 21930502
ENSP00000400142Q400*BIOMARTBreast Cancer21930507, 21930502
ENSP00000385726G245VTCGAOvarian Cancer21720365, 18772890
ENSP00000381031G245VCOSMICOvarian Cancer21720365
ENSP00000385726T413ATCGAOvarian Cancer21720365, 18772890
ENSP00000381031T414ACOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000381031Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.420804217

Hyperphosphorylation site
EWS_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANEWS_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005622intracellularIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0000166nucleotide bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005516calmodulin bindingIEAmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0003676nucleic acid bindingIEAmolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23