| UniProt/SwissProt ID: | ETV5_HUMAN |
| Description: | ets variant 5 [Source:HGNC Symbol;Acc:3494] |
| Location: | chr3 q27.2 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S248 | YHRQMsEPIVP | ETS_PEA3_N | PhosphoSitePlus |
| Y5 | _MDGFyDQQVP | ETS_PEA3_N | PhosphoSitePlus |
| S310 | VPNCQsSYMRG | ETS_PEA3_N | PhosphoSitePlus |
| S367 | YQRRGsLQLWQ | PKA_group | phosphoELM |
| Y443 | VAGERyVYKFV | Ets | PhosphoSitePlus |
| S367 | YQRRGsLQLWQ | Ets | PhosphoSitePlus |
| Dephosphorylation site |
| ETV5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000413755 | Y445C | COSMIC | Melanoma | 20016485 | ENSP00000306894 | P182L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000413755 | P182L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000413755 | N77H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000413755 | R18Q | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000306894 | P148L | COSMIC | Skin Cancer | 21984974 | ENSP00000306894 | R18Q | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000306894 | P148L | COSMIC | Skin Cancer | 21984974 | ENSP00000413755 | D452H | COSMIC | Breast Cancer | 17932254 | ENSP00000306894 | D452H | COSMIC | Breast Cancer | 17932254 | ENSP00000306894 | F191L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000306894 | Y445C | COSMIC | Melanoma | 20016485 | ENSP00000306894 | R18Q | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000413755 | F191L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000306894 | N77H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000413755 | P148L | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| ETV5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ETV5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ETV5_HUMAN | MMP1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ETV5_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0060252 | positive regulation of glial cell proliferation | IEA | biological_process |
| GO:0071340 | skeletal muscle acetylcholine-gated channel cluste | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0048133 | male germ-line stem cell division | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0007610 | behavior | IEA | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0050807 | regulation of synapse organization | IEA | biological_process |
| GO:0007274 | neuromuscular synaptic transmission | IEA | biological_process |
| GO:0034599 | cellular response to oxidative stress | IDA | biological_process |
| GO:0044212 | transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045666 | positive regulation of neuron differentiation | IEA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0060762 | regulation of branching involved in mammary gland | IEA | biological_process |