| UniProt/SwissProt ID: | EPS15_HUMAN |
| Description: | epidermal growth factor receptor pathway substrate 15 [Source:HGNC Symbol;Acc:3419] |
| Location: | chr1 p32.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T663 | FFRQStDPFAT | PhosphoSitePlus | |
| S562 | ESPARsSPELL | PhosphoSitePlus; HPRD; phosphoELM | |
| T779 | KIGTPtRPCPL | PhosphoSitePlus | |
| T777 | PPKIGtPTRPC | PhosphoSitePlus; HPRD; phosphoELM | |
| S467 | AELEEsVESGK | PhosphoSitePlus; HPRD | |
| S470 | EESVEsGKAQL | PhosphoSitePlus; HPRD | |
| S315 | PSDRAsLQKNI | PhosphoSitePlus | |
| S851 | FSAYPsEEDMI | PhosphoSitePlus | |
| S814 | FPGNDsPKEKD | PhosphoSitePlus; HPRD; phosphoELM | |
| Y443 | SQISTyEEELA | PhosphoSitePlus | |
| S323 | KNIIGsSPVAD | PhosphoSitePlus; HPRD; phosphoELM | |
| S796 | INKLDsPDPFK | PhosphoSitePlus; HPRD; phosphoELM | |
| S324 | NIIGSsPVADF | PhosphoSitePlus; HPRD; phosphoELM | |
| S108 | FHDTSsPLLIS | PhosphoSitePlus; HPRD | |
| S116 | LISGTsAAELP | HPRD | |
| S107 | RFHDTsSPLLI | PhosphoSitePlus; HPRD | |
| S741 | EDPFRsATSSS | PhosphoSitePlus | |
| S790 | PPGKRsINKLD | PhosphoSitePlus; HPRD | |
| S605 | PFNVDsSSLTG | PhosphoSitePlus | |
| S140 | IFDSLsPVNGF | PhosphoSitePlus; HPRD; phosphoELM | |
| S595 | DNNRHsKEEDP | PhosphoSitePlus; HPRD; phosphoELM | |
| S485 | QHLQDsQQEIS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y849 | ANFSAyPSEED | PhosphoSitePlus; phosphoELM | |
| Y849 | ANFSAyPSEED | EGFR | HPRD |
| S606 | FNVDSsSLTGP | PhosphoSitePlus | |
| S563 | SPARSsPELLP | PhosphoSitePlus; phosphoELM | |
| Dephosphorylation site |
| EPS15_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000360798 | S622C | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| EPS15_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| EPS15_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | EPS15_HUMAN | kinase -> substrate | RegPhos |
| EGFR_HUMAN | EPS15_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04144 | Endocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0048268 | clathrin coat assembly | IDA | biological_process |
| GO:0030136 | clathrin-coated vesicle | IEA | cellular_component |
| GO:0031901 | early endosome membrane | IEA | cellular_component |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0060170 | cilium membrane | IEA | cellular_component |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0016050 | vesicle organization | TAS | biological_process |
| GO:0005905 | coated pit | TAS | cellular_component |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0005905 | coated pit | IEA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0006897 | endocytosis | IEA | biological_process |
| GO:0030122 | AP-2 adaptor complex | IEA | cellular_component |
| GO:0042059 | negative regulation of epidermal growth factor rec | TAS | biological_process |
| GO:0032456 | endocytic recycling | IC | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |