Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPHA7_HUMAN
Description:EPH receptor A7 [Source:HGNC Symbol;Acc:3390]
Location:chr6 q16.1
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S501KSTSAsINNLKfn3PhosphoSitePlus
Y614IDPETyEDPNRPhosphoSitePlus
Y810PEAIQyRKFTSPkinase_TyrPhosphoSitePlus
Y597GDEELyFHFKFCD34_antigenPhosphoSitePlus
Y791DPEAVyTTTGGHPRD
S768NILVNsNLVCKPkinase_TyrPhosphoSitePlus
S307SDKEGsSRCECGCC2_GCC3; DUF2318PhosphoSitePlus
Y754LADMGyVHRDLPkinase_TyrPhosphoSitePlus
Y748AAGMRyLADMGPkinase_TyrPhosphoSitePlus
S308DKEGSsRCECEGCC2_GCC3; DUF2318PhosphoSitePlus
Y201VSVKVyYKKCWEphrin_lbdPhosphoSitePlus
T792PEAVYtTTGGKPkinase_TyrPhosphoSitePlus
S780SDFGLsRVIEDPkinase_TyrPhosphoSitePlus
Y202SVKVYyKKCWSEphrin_lbdPhosphoSitePlus
T794AVYTTtGGKIPPkinase_TyrPhosphoSitePlus
Y791DPEAVyTTTGGPkinase_TyrPhosphoSitePlus
Y608PGTKTyIDPETPhosphoSitePlus
S775LVCKVsDFGLSPkinase_TyrPhosphoSitePlus
T613YIDPEtYEDPNPhosphoSitePlus

Dephosphorylation site
EPHA7_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358309C109FBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000358309G232RGreenman2007Skin Cancer17344846, 18428421
ENSP00000358309E170KHPIColorectal Cancer17344846
ENSP00000358309R281SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000358309R426*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000358309R880MDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000358309M738IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000358309P903SGreenman2007Skin Cancer17344846, 18428421
ENSP00000358309R371WBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000358309E170KGreenman2007Intestines Cancer17344846, 18428421
ENSP00000358309R371WSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000358309R309TBIOMARTBreast Cancer21930507, 21930502
ENSP00000358309W838LBIOMARTBreast Cancer21930507, 21930502
ENSP00000358309L914VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
EPHA7_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EPHA7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EFNA3_HUMANEPHA7_HUMANligand -> receptorHPMR
EFNA1_HUMANEPHA7_HUMANligand -> receptorHPMR
EFNA2_HUMANEPHA7_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008046axon guidance receptor activityISSmolecular_function
GO:0043281regulation of cysteine-type endopeptidase activityISSbiological_process
GO:0046875ephrin receptor bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0031594neuromuscular junctionIEAcellular_component
GO:0031290retinal ganglion cell axon guidanceIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005887integral to plasma membraneIEAcellular_component
GO:0048755branching morphogenesis of a nerveISSbiological_process
GO:0004713protein tyrosine kinase activityISSmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005004GPI-linked ephrin receptor activityIEAmolecular_function
GO:0016310phosphorylationIEAbiological_process
GO:0031952regulation of protein autophosphorylationISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0048755branching morphogenesis of a nerveIEAbiological_process
GO:0008046axon guidance receptor activityIEAmolecular_function
GO:0048013ephrin receptor signaling pathwayIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0045499chemorepellent activityISSmolecular_function
GO:0050919negative chemotaxisIEAbiological_process
GO:0050919negative chemotaxisISSbiological_process
GO:0043525positive regulation of neuron apoptotic processISSbiological_process
GO:0022407regulation of cell-cell adhesionISSbiological_process
GO:0005003ephrin receptor activityIEAmolecular_function
GO:0045211postsynaptic membraneIEAcellular_component
GO:0030425dendriteIEAcellular_component
GO:0007420brain developmentIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0050730regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0022407regulation of cell-cell adhesionIEAbiological_process
GO:0050730regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0045499chemorepellent activityIEAmolecular_function
GO:0016310phosphorylationISSbiological_process
GO:0031952regulation of protein autophosphorylationIEAbiological_process
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0070372regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0048013ephrin receptor signaling pathwayIEAbiological_process
GO:0005004GPI-linked ephrin receptor activityISSmolecular_function
GO:0043281regulation of cysteine-type endopeptidase activityIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0007420brain developmentISSbiological_process


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