| UniProt/SwissProt ID: | EPCR_HUMAN |
| Description: | protein C receptor, endothelial [Source:HGNC Symbol;Acc:9452] |
| Location: | chr20 q11.22 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T204 | TKGSQtSRSYT | PhosphoSitePlus | |
| S195 | VQKHIsAENTK | PhosphoSitePlus | |
| Dephosphorylation site |
| EPCR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000216968 | Q83* | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000216968 | Breast Cancer | Treatment (tamoxifen-sensitive vs. tamoxifen-resistant) | tissue | Down | 0.52 | 19329653 |
| Hyperphosphorylation site |
| EPCR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PROC_HUMAN | EPCR_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| EPCR_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0019882 | antigen processing and presentation | IEA | biological_process |
| GO:0006955 | immune response | IEA | biological_process |
| GO:0050819 | negative regulation of coagulation | IMP | biological_process |
| GO:0005813 | centrosome | IEA | cellular_component |
| GO:0042612 | MHC class I protein complex | IEA | cellular_component |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0007596 | blood coagulation | IEA | biological_process |