Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EP400_HUMAN
Description:E1A binding protein p400 [Source:HGNC Symbol;Acc:11958]
Location:chr12 q24.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y120HGSPSyIQVTSPhosphoSitePlus
S196VFQDGsGLTQIHPRD
S140SPTQPsPGPGQPhosphoSitePlus
S729VNRPSsATNKAPhosphoSitePlus
S974DGEDTsGEEDAHPRD
Y386EVFKEyLIELFPhosphoSitePlus
T918DDEEEtIEEEEHPRD
T1010PDGEDtSGEEDPhosphoSitePlus
S2608ITTGGsAAVLAPhosphoSitePlus
S186SLSPSsGGHFVPhosphoSitePlus
T908ASISLtDDEVDHPRD
T3152AVRLKtPTKPPPhosphoSitePlus
T1483VAFPStHPPRTPhosphoSitePlus
S119EHGSPsYIQVTPhosphoSitePlus
S135QVQTQsPTQPSPhosphoSitePlus
S1011DGEDTsGEEDAPhosphoSitePlus
S2086EFVVLsQEPSVPhosphoSitePlus
T2813AVGKLtPEHLIPhosphoSitePlus
S2619NKRLAsPVAPGHPRD
S699TNKALsPVTSRHPRD
T945ASISLtDDEVDPhosphoSitePlus; phosphoELM
T2567AQPAItTGGSAHPRD
S934LDSGMsGRKRKPhosphoSitePlus
T1738PIGGPtQEEKTphosphoELM
S117RFEHGsPSYIQPhosphoSitePlus
S1431EAELLsKKKIPPhosphoSitePlus
S2696TPDLVsMATTQPhosphoSitePlus
S2049EFVVLsQEPSVHPRD
T314AGFGMtSPPPPHPRD; phosphoELM
T2615AVLAGtIKTSVPhosphoSitePlus
S943RKASIsLTDDEPhosphoSitePlus; phosphoELM
S321PPPPTsPSRTAPhosphoSitePlus; HPRD; phosphoELM
T3002AQQITtPGAQQPhosphoSitePlus
T2652VGSPAtATPDLHPRD
S755PTKPQsPAQNAPhosphoSitePlus; phosphoELM
S1510SSTAAsPAHPAHPRD
T2747PGKTItPAHFQPhosphoSitePlus
S1695ASKPAsPIGGPHPRD
S906RKASIsLTDDEHPRD
S2734LVPQVsQATGVPhosphoSitePlus
S904RKRKAsISLTDHPRD
S736TNKALsPVTSRPhosphoSitePlus; phosphoELM
T1701PIGGPtQEEKTHPRD
S936HQTELsNLAKEHPRD
S1276RPYLSsPLRAPSNF2_NPhosphoSitePlus
S2656NKRLAsPVAPGPhosphoSitePlus
S224RERRPsQPHTQPhosphoSitePlus
Y2284KLPPVyVRKERPhosphoSitePlus
S128VTSPLsQQVQTPhosphoSitePlus
T217PGTPItVRERRPhosphoSitePlus
S2297HKTDPsAAGRKPhosphoSitePlus
S315GFGMTsPPPPTPhosphoSitePlus; HPRD; phosphoELM
S2571ITTGGsAAVLAHPRD
S181LVRQIsLSPSSPhosphoSitePlus; HPRD
S973HQTELsNLAKEPhosphoSitePlus
T137QTQSPtQPSPGPhosphoSitePlus
S323PPTSPsRTAVPPhosphoSitePlus
S1732ASKPAsPIGGPPhosphoSitePlus; phosphoELM
S684PSPARsSPVNRHPRD
S1482TVAFPsTHPPRPhosphoSitePlus
T2776AVGKLtPEHLIHPRD
S1700PAGGPsPAPLTPhosphoSitePlus
T933VVDHQtELSNLHPRD
T320SPPPPtSPSRTPhosphoSitePlus; HPRD; phosphoELM
S1275SRPYLsSPLRASNF2_NPhosphoSitePlus
S1912LQKLKsEGRRVPhosphoSitePlus
T2996VQQKItAQQITPhosphoSitePlus
T133SQQVQtQSPTQPhosphoSitePlus
T2691SPATAtPDLVSPhosphoSitePlus
S183RQISLsPSSGGPhosphoSitePlus; HPRD
S941RKRKAsISLTDPhosphoSitePlus; phosphoELM
T2568QPAITtGGSAAHPRD
S125YIQVTsPLSQQPhosphoSitePlus
S1728EPGTAsKPASPPhosphoSitePlus; phosphoELM
S718PTKPQsPAQNAHPRD
T214LQHPGtPITVRPhosphoSitePlus
T1564TAQAStPGQPPPhosphoSitePlus
T2578AVLAGtIKTSVHPRD
S1691EPGTAsKPASPHPRD
T2814AVGKLtPEHLIphosphoELM

Dephosphorylation site
EP400_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000374212H1938PTCGAOvarian Cancer21720365, 18772890
ENSP00000330620C1290SBIOMARTBreast Cancer21930507, 21930502
ENSP00000374213Q377*COSMICCentral Nervous System Neoplasms18772890
ENSP00000374212V2938IBIOMARTBreast Cancer21930507, 21930502
ENSP00000374213P54SCOSMICSkin Cancer21984974
ENSP00000439509H1938PTCGAOvarian Cancer21720365, 18772890
ENSP00000374213C1289SBIOMARTBreast Cancer21930507, 21930502
ENSP00000374212Q377*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000331737V2901IBIOMARTBreast Cancer21930507, 21930502
ENSP00000374213V2937IBIOMARTBreast Cancer21930507, 21930502
ENSP00000333602C1326SBIOMARTBreast Cancer21930507, 21930502
ENSP00000374213R1400WCOSMICOvarian Cancer21720365
ENSP00000374213M1640ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000374213E2169KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000330620V2857IBIOMARTBreast Cancer21930507, 21930502
ENSP00000439509Q377*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000374213H1937PCOSMICOvarian Cancer21720365
ENSP00000374213P1773LCOSMICMelanoma21499247
ENSP00000333602V2974IBIOMARTBreast Cancer21930507, 21930502
ENSP00000374213Q57ECOSMICHead and Neck Cancer21798893
ENSP00000331737C1253SBIOMARTBreast Cancer21930507, 21930502
ENSP00000374212C1290SBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
EP400_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EP400_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TRIB3_HUMANEP400_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANEP400_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
EP400_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004386helicase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0016607nuclear speckIEAcellular_component
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0035267NuA4 histone acetyltransferase complexIDAcellular_component
GO:0043967histone H4 acetylationIDAbiological_process
GO:0043968histone H2A acetylationIDAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0016607nuclear speckISScellular_component
GO:0003677DNA bindingIEAmolecular_function