Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ENPL_HUMAN
Description:heat shock protein 90kDa beta (Grp94), member 1 [Source:HGNC Symbol;Acc:12028]
Location:chr12 q23.3
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S42KSREGsRTDDEPhosphoSitePlus
S92KLIINsLYKNKPhosphoSitePlus; HPRD
T519SSHHPtDITSLHPRD
T150LHVTDtGVGMTHPRD
S515LRFQSsHHPTDHPRD
T44REGSRtDDEVVPhosphoSitePlus
Y652LVASQyGWSGNHSP90PhosphoSitePlus
Y677DISTNyYASQKHSP90PhosphoSitePlus
T684ASQKKtFEINPHPRD
T148NLLHVtDTGVGHPRD
T165VKNLGtIAKSGHATPase_cPhosphoSitePlus
T604DESEKtKESREHPRD
Y677DISTNyYASQKHPRD; phosphoELM
T684ASQKKtFEINPHSP90PhosphoSitePlus
Y408SKKSDyIKLYVHSP90PhosphoSitePlus
Y735PDTKAyGDRIEHSP90PhosphoSitePlus
S544YFMAGsSRKEAHSP90PhosphoSitePlus
Y678ISTNYyASQKKHSP90PhosphoSitePlus
Y200FGVGFySAFLVHATPase_cPhosphoSitePlus
S201GVGFYsAFLVAHATPase_cPhosphoSitePlus
S306EEKEEsDDEAAHSP90PhosphoSitePlus
T179FLNKMtEAQEDHATPase_cPhosphoSitePlus
Y429DMMPKyLNFVKHSP90PhosphoSitePlus
S106LRELIsNASDAHATPase_cPhosphoSitePlus
T786EMDVGtDEEEEPhosphoSitePlus; HPRD; phosphoELM
S109LISNAsDALDKHATPase_cPhosphoSitePlus
T774DTTEDtEQDEDHPRD
T468KLVRKtLDMIKHSP90PhosphoSitePlus
S306EEKEEsDDEAAHPRD
S545FMAGSsRKEAEHSP90PhosphoSitePlus
S347IWQRPsKEVEEHSP90PhosphoSitePlus
Y94IINSLyKNKEIPhosphoSitePlus; HPRD
S187QEDGQsTSELIHATPase_cPhosphoSitePlus
Y667MKAQAyQTGKDHSP90PhosphoSitePlus
T792DEEEEtAKESTHPRD

Dephosphorylation site
ENPL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000299767G8RCOSMICOvarian Cancer21720365
ENSP00000299767R156KCOSMICOvarian Cancer20826764
ENSP00000299767S601NCOSMICMelanoma21499247

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000299767Hepatocellular CarcinomaNormal vs. Cancercell lineUp3.318646787
ENSP00000299767Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000299767Hepatocellular CarcinomaNormal vs. CancertissueUp2.117627933
ENSP00000299767Prostate CancerMetastasiscell lineUp1.618232632
ENSP00000299767follicular thyroid carcinomaNormal vs. CancertissueDown0.2818316623
ENSP00000299767follicular thyroid carcinomaNormal vs. CancertissueDown0.618316623
ENSP00000299767Oral Premalignant LesionsNormal vs. CancertissueUp2.919072117
ENSP00000299767Oral Premalignant LesionsNormal vs. CancertissueUp1.619072117
ENSP00000299767Oral Premalignant LesionsNormal vs. CancertissueUp1.219072117
ENSP00000299767Oral Premalignant LesionsNormal vs. CancertissueUp1.519072117
ENSP00000299767Oral Premalignant LesionsNormal vs. CancertissueUp3.419072117
ENSP00000299767Oral Premalignant LesionsNormal vs. CancertissueDown0.819072117
ENSP00000299767Oral Premalignant LesionsNormal vs. CancertissueDown0.9919072117
ENSP00000299767Esophageal CancerNormal vs. CancertissueDown0.2319142970
ENSP00000299767Esophageal CancerNormal vs. CancertissueDown0.4819142970
ENSP00000299767Breast CancerNormal vs. Cancercell lineDown0.2916596714
ENSP00000299767Hepatocellular CarcinomaNormal vs. CancertissueUp2.611866469
ENSP00000299767hepatitis B virusNormal vs. CancertissueUp5.714654528
ENSP00000299767hepatitis C virusNormal vs. CancertissueUp5.714654528
ENSP00000299767Hepatocellular CarcinomaNormal vs. CancertissueUp5.714654528
ENSP00000299767Hepatocellular CarcinomaTreatment (none vs. Suberonylanilide hydroxamic acid (SAHA) treatment)tissueDown17593366
ENSP00000299767Hepatocellular CarcinomaNormal vs. CancertissueUp18571811
ENSP00000299767Hepatocellular CarcinomaNormal vs. CancertissueUp18937283
ENSP00000299767Lung CancerTreatment(none vs transfected with HPV-16 E7 gene)cell lineUp15684709
ENSP00000299767Brain CancerCancer vs. Cancercell lineUp15750928
ENSP00000299767Neoplasms by Histologic TypeCancer vs. Cancercell lineUp15750928
ENSP00000299767Neoplasms by Histologic TypeCancer vs. Cancercell lineUp15750928
ENSP00000299767Gastric CancerNormal vs. CancertissueUp14711373
ENSP00000299767Breast CancerMetastasiscell lineUp2.918729497
ENSP00000299767Breast CancerNormal vs. Cancercell lineUp2.420052998
ENSP00000299767Breast CancerNormal vs. Cancercell lineUp1.120052998
ENSP00000299767Breast CancerMetastasiscell lineDown0.5320052998
ENSP00000299767Breast CancerCancer vs. Cancer (Non-TNBC vs. TNBC)cell lineUp20596302
ENSP00000299767breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000299767MelanomaTreatment (none vs. kojic acid treatment)cell lineDown0.6618630942
ENSP00000299767MelanomaTreatment (none vs. kojic acid treatment)cell lineDown0.9118630942
ENSP00000299767Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueDown0.3919422301
ENSP00000299767Pancreatic CancerNormal vs. CancertissueDown0.3315526344
ENSP00000299767Gastric CancerNormal vs. CancertissueDown0.5615761955
ENSP00000299767Hepatocellular CarcinomaNormal vs. CancertissueUp2.611866469

Hyperphosphorylation site
ENPL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ENPL_HUMANLRP1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa04141Protein processing in endoplasmic reticulum
hsa05215Prostate cancer
hsa04621NOD-like receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005509calcium ion bindingTASmolecular_function
GO:0030433ER-associated protein catabolic processIMPbiological_process
GO:0051082unfolded protein bindingIEAmolecular_function
GO:0001666response to hypoxiaIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0051208sequestering of calcium ionNASbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0005829cytosolIDAcellular_component
GO:0042470melanosomeIEAcellular_component
GO:0019903protein phosphatase bindingIDAmolecular_function
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0005789endoplasmic reticulum membraneIDAcellular_component
GO:0050750low-density lipoprotein particle receptor bindingIDAmolecular_function
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0030496midbodyIDAcellular_component
GO:0015031protein transportNASbiological_process
GO:0044459plasma membrane partIEAcellular_component
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0046790virion bindingIPImolecular_function
GO:0043666regulation of phosphoprotein phosphatase activityIDAbiological_process
GO:0006950response to stressIEAbiological_process
GO:0071318cellular response to ATPIDAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0005788endoplasmic reticulum lumenIDAcellular_component
GO:0003723RNA bindingIDAmolecular_function
GO:0031247actin rod assemblyIDAbiological_process
GO:0006457protein foldingIEAbiological_process