| UniProt/SwissProt ID: | ENAH_HUMAN |
| Description: | enabled homolog (Drosophila) [Source:HGNC Symbol;Acc:18271] |
| Location: | chr1 q42.12 |
| Node attribute: | PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S528 | VFDNRsYDSLH | PhosphoSitePlus | |
| S265 | RERRIsSAAAP | PhosphoSitePlus | |
| S486 | TSKASsTSTPE | PhosphoSitePlus | |
| T487 | SKASStSTPEP | PhosphoSitePlus | |
| T116 | LNSQEtGPTLP | PhosphoSitePlus | |
| S405 | KLRKVsRMEDT | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T481 | DSEPVtSKASS | PhosphoSitePlus | |
| T517 | SRPKStPLSQP | HPRD | |
| S506 | NTMNGsKSPVI | PhosphoSitePlus; HPRD; phosphoELM | |
| S512 | KSPVIsRRDSP | PhosphoSitePlus | |
| T500 | KPWERtNTMNG | PhosphoSitePlus | |
| S520 | KSTPLsQPSAN | HPRD | |
| S516 | ISRRDsPRKNQ | PhosphoSitePlus | |
| T502 | WERTNtMNGSK | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S541 | KSTPLsQPSAN | HPRD; phosphoELM | |
| S266 | ERRISsAAAPA | PhosphoSitePlus | |
| T410 | SRMEDtSFPSG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S508 | MNGSKsPVISR | PhosphoSitePlus; HPRD; phosphoELM | |
| T119 | QETGPtLPRQN | PhosphoSitePlus | |
| Y529 | FDNRSyDSLHR | PhosphoSitePlus | |
| T538 | HRPKStPLSQP | HPRD; phosphoELM | |
| T489 | ASSTStPEPTR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y16 | AAVMVyDDANK | WH1 | PhosphoSitePlus |
| S485 | VTSKAsSTSTP | PhosphoSitePlus | |
| S125 | LPRQNsQLPAQ | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Dephosphorylation site |
| ENAH_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000355808 | Q130* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000355809 | R240W | COSMIC | Melanoma | 21499247 | ENSP00000355808 | Q151K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000355809 | Q151K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000355809 | S531T | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000355809 | Q130* | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000355809 | Ovarian Cancer | Metastasis | cell line | Up | 17892554 | |
| Hyperphosphorylation site |
| ENAH_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| BAIP2_HUMAN | ENAH_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0050852 | T cell receptor signaling pathway | TAS | biological_process |
| GO:0030036 | actin cytoskeleton organization | IEA | biological_process |
| GO:0030054 | cell junction | IDA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0030175 | filopodium | IEA | cellular_component |
| GO:0001843 | neural tube closure | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005925 | focal adhesion | IDA | cellular_component |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0046907 | intracellular transport | IEA | biological_process |
| GO:0050699 | WW domain binding | IPI | molecular_function |
| GO:0045202 | synapse | IEA | cellular_component |
| GO:0030027 | lamellipodium | IEA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0001725 | stress fiber | IEA | cellular_component |
| GO:0007411 | axon guidance | IEA | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0008154 | actin polymerization or depolymerization | IEA | biological_process |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0003779 | actin binding | IEA | molecular_function |