Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EFTU_HUMAN
Description:Tu translation elongation factor, mitochondrial [Source:HGNC Symbol;Acc:12420]
Location:chr16 p11.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S267VEAVYsVPGRGPhosphoSitePlus
T77GKTTLtAAITKHPRD
Y266PVEAVySVPGRPhosphoSitePlus
Y246DAVDTyIPVPAGTP_EFTUPhosphoSitePlus
Y133PGHADyVKNMIGTP_EFTUPhosphoSitePlus

Dephosphorylation site
EFTU_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000322439T207PCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000322439Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineDown0.5716319398
ENSP00000322439Breast CancerNormal vs. Cancercell lineDown0.714997480
ENSP00000322439Breast CancerNormal vs. Cancercell lineDown0.414997480
ENSP00000322439hepatitis B virusNormal vs. CancertissueDown0.3115852300
ENSP00000322439Breast CancerNormal vs. CancertissueUp1.720087651
ENSP00000322439Breast CancerCancer vs. Cancer (Non-TNBC vs. TNBC)cell lineUp20596302
ENSP00000322439Renal CancerNormal vs. CancertissueDown19164279
ENSP00000322439Renal CancerNormal vs. CancertissueDown0.4519610612
ENSP00000322439Testicular CancerNormal vs. Cancercell lineUp18489135
ENSP00000322439Pancreatic CancerNormal vs. CancertissueUp<215526344
ENSP00000322439Biliary Tract CancerMetastasiscell lineDown0.3219299076

Hyperphosphorylation site
EFTU_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KKCC2_HUMANEFTU_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
EFTU_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005525GTP bindingIEAmolecular_function
GO:0042645mitochondrial nucleoidIDAcellular_component
GO:0006414translational elongationIDAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0003746translation elongation factor activityIDAmolecular_function
GO:0003924GTPase activityIEAmolecular_function
GO:0005739mitochondrionIDAcellular_component


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