| UniProt/SwissProt ID: | EFTU_HUMAN |
| Description: | Tu translation elongation factor, mitochondrial [Source:HGNC Symbol;Acc:12420] |
| Location: | chr16 p11.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S267 | VEAVYsVPGRG | PhosphoSitePlus | |
| T77 | GKTTLtAAITK | HPRD | |
| Y266 | PVEAVySVPGR | PhosphoSitePlus | |
| Y246 | DAVDTyIPVPA | GTP_EFTU | PhosphoSitePlus |
| Y133 | PGHADyVKNMI | GTP_EFTU | PhosphoSitePlus |
| Dephosphorylation site |
| EFTU_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000322439 | T207P | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000322439 | Ovarian Cancer | Treatment (cisplatin-sensitive vs. cisplatin-resistant) | cell line | Down | 0.57 | 16319398 | ENSP00000322439 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.7 | 14997480 | ENSP00000322439 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.4 | 14997480 | ENSP00000322439 | hepatitis B virus | Normal vs. Cancer | tissue | Down | 0.31 | 15852300 | ENSP00000322439 | Breast Cancer | Normal vs. Cancer | tissue | Up | 1.7 | 20087651 | ENSP00000322439 | Breast Cancer | Cancer vs. Cancer (Non-TNBC vs. TNBC) | cell line | Up | 20596302 | ENSP00000322439 | Renal Cancer | Normal vs. Cancer | tissue | Down | 19164279 | ENSP00000322439 | Renal Cancer | Normal vs. Cancer | tissue | Down | 0.45 | 19610612 | ENSP00000322439 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | ENSP00000322439 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | <2 | 15526344 | ENSP00000322439 | Biliary Tract Cancer | Metastasis | cell line | Down | 0.32 | 19299076 |
| Hyperphosphorylation site |
| EFTU_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KKCC2_HUMAN | EFTU_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| EFTU_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0042645 | mitochondrial nucleoid | IDA | cellular_component |
| GO:0006414 | translational elongation | IDA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0003746 | translation elongation factor activity | IDA | molecular_function |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005739 | mitochondrion | IDA | cellular_component |