Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EF1B_HUMAN
Description:eukaryotic translation elongation factor 1 beta 2 [Source:HGNC Symbol;Acc:3208]
Location:chr2 q33.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S8FGDLKsPAGLQPhosphoSitePlus; HPRD; SysPTM
S90EDTTGsGATDSPhosphoSitePlus; HPRD
Y18QVLNDyLADKSHPRD
T87ADVEDtTGSGAPhosphoSitePlus; HPRD; phosphoELM
Y182LVPVGyGIKKLEF1_GNEPhosphoSitePlus
Y213TAFEDyVQSMDEF1_GNEPhosphoSitePlus
T88DVEDTtGSGATPhosphoSitePlus; HPRD
S95SGATDsKDDDDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S106IDLFGsDDEEECK2a1-rsRegPhos; SysPTM
S112DDEEEsEEAKRCK2a1-rsRegPhos; SysPTM
S112DDEEEsEEAKRPhosphoSitePlus; HPRD; SysPTM
S106IDLFGsDDEEECK2a1RegPhos; SysPTM
S106IDLFGsDDEEECK2a2RegPhos; SysPTM
Y79KALGKyGPADVPhosphoSitePlus; HPRD
S106IDLFGsDDEEECSNK2A2HPRD; SysPTM
S128LAQYEsKKAKKPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S106IDLFGsDDEEECSNK2A1HPRD; SysPTM
S112DDEEEsEEAKRCK2a2RegPhos; SysPTM
S112DDEEEsEEAKRCK2a1RegPhos; SysPTM
Y126ERLAQyESKKAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S106IDLFGsDDEEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S112DDEEEsEEAKRCSNK2A2HPRD; SysPTM
S112DDEEEsEEAKRCSNK2A1HPRD; SysPTM
S141LVAKSsILLDVHPRD; phosphoELM; RegPhos
S141LVAKSsILLDVEF1_GNEPhosphoSitePlus
T93TGSGAtDSKDDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM

Dephosphorylation site
EF1B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376055*226YCOSMICOvarian Cancer21720365
ENSP00000376056*226YCOSMICOvarian Cancer21720365
ENSP00000236957*226YCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000376055LeukemiaNormal vs. Cancercell lineDown0.2317022645
ENSP00000376055LeukemiaNormal vs. Cancercell lineDown0.3617022645
ENSP00000376055Breast CancerNormal vs. CancertissueUp17127214
ENSP00000376055Breast CancerMetastasiscell lineDown0.7718582095
ENSP00000376055Breast CancerNormal vs. CancertissueUp4.420005186
ENSP00000376055Breast CancerNormal vs. CancertissueUp20560667
ENSP00000376055Oral CancerNormal vs. CancertissueUp2.419691830
ENSP00000376055acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.0117655343
ENSP00000376055acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1117655343
ENSP00000376055acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.3717655343
ENSP00000376055acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1417655343
ENSP00000376055acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1717655343
ENSP00000376055acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.3117655343
ENSP00000376055acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.3917655343

Hyperphosphorylation site
EF1B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK22_HUMANEF1B_HUMANkinase -> substrateHPRD
CSK21_HUMANEF1B_HUMANkinase -> substrateHPRD
ZAGL2_HUMANEF1B_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
EF1B_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0010467gene expressionTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005829cytosolTAScellular_component
GO:0006414translational elongationNASbiological_process
GO:0006412translationTASbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0005853eukaryotic translation elongation factor 1 complexIEAcellular_component
GO:0003746translation elongation factor activityIEAmolecular_function


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