Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ECT2_HUMAN
Description:epithelial cell transforming sequence 2 oncogene [Source:HGNC Symbol;Acc:3155]
Location:chr3 q26.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T422LDISNtPESSIPhosphoSitePlus
S5_MAENsVLTSTPhosphoSitePlus
T342MLSLNtPNSNRHPRD; phosphoELM
S391TLAQLsRETDVPhosphoSitePlus
T342MLSLNtPNSNRCDC2(CDK1RegPhos
S909HTLSRsTTHLIPhosphoSitePlus
S883LSSTSsLAGIPPhosphoSitePlus
S811VTRAFsFSKTPHPRD; phosphoELM
T373MLSLNtPNSNRPhosphoSitePlus
S907RSHTLsRSTTHPhosphoSitePlus
S420SLLDIsNTPESPhosphoSitePlus
S442TKSSKsSTPVPPhosphoSitePlus
S685IGTFRsPHGQTHPRD
T881SRLSStSSLAGPhosphoSitePlus
S406PRKRPsAEHSLPhosphoSitePlus
S376LNTPNsNRKRRPhosphoSitePlus
S879VMSRLsSTSSLPhosphoSitePlus
S860GIPSPsLVSLPphosphoELM
S891GIPSPsLVSLPPhosphoSitePlus
T444SSKSStPVPSKPhosphoSitePlus
S858LAGIPsPSLVSHPRD; phosphoELM
T846FSFSKtPKRALPhosphoSitePlus
S412AEHSLsIGSLLPhosphoSitePlus
Y539DIFLKySKDLVRhoGEFPhosphoSitePlus
S339SVSMLsLNTPNHPRD; phosphoELM
S716IGTFRsPHGQTPhosphoSitePlus
S842VTRAFsFSKTPPhosphoSitePlus
T815FSFSKtPKRALCDC2RegPhos
S411TKSSKsSTPVPphosphoELM; RegPhos
S861MTSHGsVEGRSPhosphoSitePlus
S345LNTPNsNRKRRHPRD; phosphoELM
T359YEKANtPELKKPhosphoSitePlus
T413SSKSStPVPSKCDK1phosphoELM
S889LAGIPsPSLVSPhosphoSitePlus
T911LSRSTtHLI__PhosphoSitePlus
S880MSRLSsTSSLAPhosphoSitePlus
T342MLSLNtPNSNRCDK1phosphoELM
S417STPVPsKQSARphosphoELM; RegPhos
T838TSKKVtRAFSFPhosphoSitePlus
S24SSIFDsKVTEIPhosphoSitePlus
T14STTGRtSLADSPhosphoSitePlus
S852LSSTSsLAGIPHPRD
S397RETDVsPFPPRPhosphoSitePlus
S882RLSSTsSLAGIPhosphoSitePlus
S448STPVPsKQSARPhosphoSitePlus
S15TTGRTsLADSSPhosphoSitePlus
T713HKVIGtFRSPHPhosphoSitePlus
T815FSFSKtPKRALCDK1HPRD; phosphoELM
T328YEKANtPELKKHPRD; phosphoELM; RegPhos
S336LKKSVsMLSLNHPRD; phosphoELM
T413SSKSStPVPSKCDC2(CDK1RegPhos
S370SVSMLsLNTPNPhosphoSitePlus
T815FSFSKtPKRALphosphoELM
Y41IGSTSyVEEEMHPRD; phosphoELM
T815FSFSKtPKRALCDC2(CDK1RegPhos
S602VQRLPsVALLLRhoGEFPhosphoSitePlus
S40LIGSTsYVEEEPhosphoSitePlus; HPRD; phosphoELM
T815FSFSKtPKRALPLK1HPRD; RegPhos
T910TLSRStTHLI_PhosphoSitePlus
S334PELKKsVSMLSHPRD; phosphoELM
Y244KPEWIyKAWERPhosphoSitePlus
S367LKKSVsMLSLNPhosphoSitePlus

Dephosphorylation site
ECT2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000412259P588SCOSMICMelanoma
ENSP00000412259L650VBIOMARTBreast Cancer21930507, 21930502
ENSP00000232458K817EBIOMARTBreast Cancer21930507, 21930502
ENSP00000412259E717DBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000412259E45DCOSMICOvarian Cancer21720365
ENSP00000232458S830LCOSMICBreast Cancer20668451
ENSP00000412259S830LCOSMICBreast Cancer20668451
ENSP00000232458E354QCOSMICHead and Neck Cancer21798893
ENSP00000376457T833PHPIBreast Cancer16959974
ENSP00000443160T833PHPIBreast Cancer16959974
ENSP00000412259K817EBIOMARTBreast Cancer21930507, 21930502
ENSP00000232458E45DCOSMICOvarian Cancer21720365
ENSP00000412259E354QCOSMICHead and Neck Cancer21798893
ENSP00000232458L650VBIOMARTBreast Cancer21930507, 21930502
ENSP00000412259T802PCOSMICBreast Cancer16959974
ENSP00000232458T802PSjoblom2006, COSMICBreast Cancer16959974
ENSP00000232458P588SCOSMICMelanoma

Differential expressed protein
ECT2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
T359YLYEKANtPELKKSVnon-small cell lung cancer21189248PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANECT2_HUMANkinase -> substrateRegPhos
PLK1_HUMANECT2_HUMANkinase -> substrateHPRD; RegPhos
CDK1_HUMANECT2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
ECT2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0070301cellular response to hydrogen peroxideIDAbiological_process
GO:0005923tight junctionIDAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0070830tight junction assemblyIMPbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIMPbiological_process
GO:0071479cellular response to ionizing radiationIDAbiological_process
GO:0005085guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0000910cytokinesisIEAbiological_process
GO:0042307positive regulation of protein import into nucleusISSbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0071777positive regulation of cell cycle cytokinesisIMPbiological_process
GO:0042307positive regulation of protein import into nucleusIEAbiological_process
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0097149centralspindlin complexIDAcellular_component
GO:0000902cell morphogenesisIEAbiological_process
GO:0005089Rho guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0032862activation of Rho GTPase activityIDAbiological_process
GO:0015031protein transportIEAbiological_process
GO:0043089positive regulation of Cdc42 GTPase activityIDAbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0032154cleavage furrowIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005911cell-cell junctionIDAcellular_component
GO:0004871signal transducer activityIMPmolecular_function
GO:0032147activation of protein kinase activityIDAbiological_process
GO:0030496midbodyIDAcellular_component
GO:0017048Rho GTPase bindingIEAmolecular_function
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0032863activation of Rac GTPase activityIMPbiological_process
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0071277cellular response to calcium ionIDAbiological_process
GO:0051988regulation of attachment of spindle microtubules tIMPbiological_process
GO:0032321positive regulation of Rho GTPase activityIDAbiological_process
GO:0005096GTPase activator activityIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0072686mitotic spindleIDAcellular_component
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0051260protein homooligomerizationIDAbiological_process
GO:0033205cell cycle cytokinesisIMPbiological_process
GO:0045859regulation of protein kinase activityIDAbiological_process


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