Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ECHB_HUMAN
Description:hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [Source:HGNC Symbol;Acc:4803]
Location:chr2 p23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S308VTAANsSFLTDHPRD
T91GLLHRtSVPKEThiolase_NPhosphoSitePlus
S316LTDGAsAMLIMThiolase_NPhosphoSitePlus
T356LLLGPtYATPKHPRD
Y336YKPKAyLRDFMThiolase_CPhosphoSitePlus
Y342LRDFMyVSQDPThiolase_CPhosphoSitePlus
T359GPTYAtPKVLEHPRD
Y357LLGPTyATPKVThiolase_CPhosphoSitePlus

Dephosphorylation site
ECHB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000325136A119VSjoblom2006, COSMIC, HPIBreast Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000325136Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.418646787
ENSP00000325136Breast CancerTreatment (Antiestrogen-sensitive vs. Antiestrogen-resistant)cell lineUp14557597
ENSP00000325136Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.620625496

Hyperphosphorylation site
ECHB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TBK1_HUMANECHB_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ECHB_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005743mitochondrial inner membraneIEAcellular_component
GO:0016747transferase activity, transferring acyl groups othIEAmolecular_function
GO:0003824catalytic activityIEAmolecular_function
GO:0016507mitochondrial fatty acid beta-oxidation multienzymIEAcellular_component
GO:0042645mitochondrial nucleoidIDAcellular_component
GO:0005741mitochondrial outer membraneIDAcellular_component
GO:00038573-hydroxyacyl-CoA dehydrogenase activityIEAmolecular_function
GO:0016508long-chain-enoyl-CoA hydratase activityIEAmolecular_function
GO:0006635fatty acid beta-oxidationIEAbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0003988acetyl-CoA C-acyltransferase activityIEAmolecular_function
GO:0051287NAD bindingIEAmolecular_function
GO:0004300enoyl-CoA hydratase activityIEAmolecular_function
GO:0006644phospholipid metabolic processTASbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0005739mitochondrionNAScellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0005740mitochondrial envelopeTAScellular_component
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0000062fatty-acyl-CoA bindingIEAmolecular_function
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0016509long-chain-3-hydroxyacyl-CoA dehydrogenase activitIEAmolecular_function
GO:0046474glycerophospholipid biosynthetic processTASbiological_process
GO:0035965cardiolipin acyl-chain remodelingTASbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23