Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EAA1_HUMAN
Description:solute carrier family 1 (glial high affinity glutamate transporter), member 3 [Source:HGNC Symbol;Acc:10941]
Location:chr5 p13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T482RLRTTtNVLGDSGK1HPRD; RegPhos
S512VEMGNsVIEENPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y523EMKKPyQLIAQPhosphoSitePlus

Dephosphorylation site
EAA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265113E378GCOSMICHepatocellular Carcinoma21822264
ENSP00000371343V321IBIOMARTBreast Cancer21930507, 21930502
ENSP00000265113V321IBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
EAA1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EAA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SGK1_HUMANEAA1_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANEAA1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04724Glutamatergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050806positive regulation of synaptic transmissionIEAbiological_process
GO:0048667cell morphogenesis involved in neuron differentiatIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0006811ion transportTASbiological_process
GO:0005314high-affinity glutamate transmembrane transporter IEAmolecular_function
GO:0006537glutamate biosynthetic processIEAbiological_process
GO:0016595glutamate bindingIEAmolecular_function
GO:0070779D-aspartate importIDAbiological_process
GO:0021545cranial nerve developmentIEAbiological_process
GO:0017153sodium:dicarboxylate symporter activityIEAmolecular_function
GO:0016597amino acid bindingIEAmolecular_function
GO:0007605sensory perception of soundIEAbiological_process
GO:0050885neuromuscular process controlling balanceIEAbiological_process
GO:0006536glutamate metabolic processIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0007268synaptic transmissionTASbiological_process
GO:0046677response to antibioticIEAbiological_process
GO:0009611response to woundingIEAbiological_process
GO:0016020membraneTAScellular_component
GO:0009416response to light stimulusIEAbiological_process
GO:0009449gamma-aminobutyric acid biosynthetic processIEAbiological_process
GO:0006835dicarboxylic acid transportIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0031223auditory behaviorIEAbiological_process
GO:0005313L-glutamate transmembrane transporter activityTASmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0051938L-glutamate importIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0043205fibrilIEAcellular_component
GO:0055085transmembrane transportTASbiological_process
GO:0001504neurotransmitter uptakeTASbiological_process
GO:0042995cell projectionIEAcellular_component
GO:0042493response to drugIEAbiological_process
GO:0015813L-glutamate transportIEAbiological_process


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