Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:E2F4_HUMAN
Description:E2F transcription factor 4, p107/p130-binding [Source:HGNC Symbol;Acc:3118]
Location:chr16 q22.1
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T14PPPPGtPSRHEPhosphoSitePlus
S310LDSSSsSSSSSPhosphoSitePlus
S309LLDSSsSSSSSPhosphoSitePlus
Y139NSCLAyVTHEDPhosphoSitePlus
S384PLLRLsPPPGDPhosphoSitePlus
T141CLAYVtHEDICPhosphoSitePlus
S312SSSSSsSSSSSPhosphoSitePlus
S311DSSSSsSSSSSPhosphoSitePlus
S21SRHEKsLGLLTE2F_TDPPhosphoSitePlus
S16PPGTPsRHEKSPhosphoSitePlus

Dephosphorylation site
E2F4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000368686D152NBIOMARTBreast Cancer21930507, 21930502
ENSP00000368686E171*BIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
E2F4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
E2F4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
E2F4_HUMANCDK1_HUMANTF -> target geneTRANSFAC
E2F4_HUMANPCNA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
E2F4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019904protein domain specific bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0000080G1 phase of mitotic cell cycleTASbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0042384cilium assemblyIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0009887organ morphogenesisIEAbiological_process
GO:0002064epithelial cell developmentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyTASbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0000083regulation of transcription involved in G1/S phaseIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0008134transcription factor bindingIPImolecular_function
GO:0006884cell volume homeostasisIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0003677DNA bindingIMPmolecular_function
GO:0008361regulation of cell sizeIEAbiological_process
GO:0008015blood circulationIEAbiological_process


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